Template:Periorbital Cellulitis Antibiotics

Antibiotics

Outpatient

Treatment recommended for 5-7 days. If signs of cellulitis persist at the end of this period, treatment should be continued until the eyelid erythema and swelling have resolved or nearly resolved.

• Trimethoprim-sulfamethoxazole 1-2 double-strength tablets BID OR

- In children: 8 to 12 mg/kg QD of the TMP component divided every 12 hours

• Clindamycin 300mg Q8H

- In children: 30 to 40 mg/kg per day in three to four equally divided doses, maximum 1.8 grams per day

PLUS one of the following agents:

• Amoxicillin 875 mg BID OR

- In children: usual dosing is 45 mg/kg per day divided every 12 hours; dosing for severe infections or when penicillin-resistant S. pneumoniae is a concern (using the 600 mg/5 mL suspension) is 90 mg/kg per day divided every 12 hours

• Cefpodoxime 400mg BID OR

- In children <12 years of age: 10 mg/kg per day divided every 12 hours, usual maximum dose 200 mg; in children ≥12 years and adolescents: 400 mg every 12 hours

• Cefdinir 300 mg BID

- In children: 14 mg/kg per day, divided every 12 hours, maximum daily dose 600 mg

Inpatient

Vancomycin 15-20mg/kg IV BID + (one of the following)

• Ampicillin/Sulbactam 3 g IV q6hr OR
• Ticarcillin/Clavulanate 3.1 g IV q4h OR
• Piperacillin-Tazobactam 4.5 g IV q6h OR
• Ceftriaxone 2 g IV q12hr OR
• Cefotaxime 2 g IV q4h