Labetalol

General

Adult Dosing

  • Bolus dosing
    • 20mg IV followed by 40-80mg q10min up to total of 300mg
  • Infusion dosing
    • 0.5-2mg/min

Pediatric Dosing

Special Populations

  • Pregnancy Rating:
  • Lactation:
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Indications

  • HTN in setting of myocardial ischemia
  • HTN in setting of neurologic injury
  • HTN in setting of preeclampsia/eclampsia

Contraindications

  • Allergy to class/drug

Adverse Reactions

  • Orthostatic hypotension

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action:
    • Class II - Nonselective beta blocker
    • Alpha1 blocker
  • Onset of action = 2-5min (IV)
  • Duration of action = 2-4hr (IV)

See Also

Sources