Template:Endometritis Antibiotics

<48hrs Post Partum

Treatment is targeted against polymicrobial infections, most often 2-3 organisms of normal vaginal flora

• (Prefered first line) Clindamycin 900mg q8hrs PLUS Gentamicin 5mg/kg IV q24hours (same efficacy and more cost effective vs. 1.5mg/kg) or 1.5mg/kg IV q8hrs OR
• Doxycycline 100mg IV PO q12hrs daily PLUS
  • Ampicillin/Sulbactam 3g IV q6hrs
  • Cefoxitin 2g IV q6hrs daily

>48hrs Post Partum

Use Metronidazole with caution in breastfeeding mothers as Metronidazole and its active hydroxyl metabolite are present in breast milk at concentrations similar to maternal plasma concentrations. Metronidazole and its active metabolite can be detected in the serum of breastfeeding infants (Gray 1961; Heisterberg 1983; Passmore 1988)

• Doxycycline 100mg IV or PO q12hrs + Metronidazole 500mg IV or PO q8hrs daily