Lymphoma

Hodgkin's lymphoma

Background

• Spreads from source lymph node to adjacent nodes
• Bimodal distribution: young adulthood and older aged
• Most common malignancy between ages of 15-19 yo
• Survival >90% in low-risk pts

Diagnosis

• Painless, firm, lymph node (usually cervical or supraclavicular)
• "B" symptoms: fever, night sweats, wt loss

Work-Up

• CXR
• CT neck/C/A/P
• LN biopsy

DDx

Cervical lymphadenopathy

1. Non-Hodgkin lymphoma
2. Mononucleosis
3. Toxoplasmosis
4. Branchial cleft lesions
5. Cat scratch disease
6. Mycobacterial adenitis

Treatment

• Manage acute complications
  • Superior vena cava syndrome
  • Upper airway compression
    • Do NOT give steroids

See Also

• Oncologic emergencies

Non-Hodgkin Lymphoma

Background

• May originate in lymphatic system or any organ in the body
• Occurs in children >5yr old
• Risk factors
  • Immunosuppression (HIV, Crohn, chemo recipients)

Diagnosis

• Lymphadenopathy
• Hepatosplenomegaly
• "B" symptoms
• GI
  • Bleeding, intussusception, N/V

Work-Up

• CBC
• Chemistry
• Uric acid
• LFT
• CXR

Complications

• Superior vena cava syndrome
• Pleural/pericardial effusions
• Spinal cord compression

Source

Tintinalli

See Also

Acute Leukemia