Platelet transfusion

General

• Type:
• Dosage Forms:
• Common Trade Names:

Adult Dosing

Thrombocytopenia

• 1 unit raises count by 50K

Special Populations

• Pregnancy Rating:
• Lactation:
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Indications

• Plt count <10K in asymptomatic patients (unless due to ITP, TTP, or HIT)
• Plt count <15K with a coagulation disorder or minor bleeding
• Plt count <20K with major bleeding
• Plt count <50K with need for invasive procedure or surgery
• Plt count <100K with need for neurologic or cardiac surgery

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action:

Comments

• Transfusion should be type specific because platelets are bathed in plasma
  • Non-type specific platelets can be used but results in higher rate of complications
• Like pRBCs, platelets can be leukocyte reduced or washed

See Also

• Transfusions
• Thrombocytopenia