Rho(D) immune globulin

General

• Type:
• Dosage Forms:
• Routes of Administration:
• Common Trade Names:

Special Populations

• Pregnancy Rating:
• Lactation risk:
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Contraindications

• Allergy to class/drug
• Prior sensitization of mother
• Known Rh-negative father
• Known Rh-negative fetus (from cord blood)

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action:

See Also

• Vaginal Bleeding (Main)

Background

• For fetal maternal hemorrhage
• Risk = >4-12wks
• Also given to Rh- male trauma patients who receive O+ blood to prevent future reaction with O+ transfusions

Treatment

• 1st Trimester (through 12weeks)
  • --> give 50 microgm IM
    • (although there is no harm in giving the standard 300 microgram dose, which is more readily available)
• 2nd & 3rd Trimester
  • --> give 300 microgm IM once and send Kleihauer-Betke test
  • --> within 72hrs give additional 300 microgm/15 ml Rh-positive blood