Lactulose

General

• Type: osmotic laxative
• Dosage Forms: 10g/15L solution
• Routes of Administration: oral, NG, rectal
• Common Trade Names: Kristalose

Adult Dosing

Hepatic encephalopathy

• 30-45mg PO TID or QID or (300mL in 700cc H2O retention enema x30min)
  • titrate for 2-3 soft stools per day

constipation

• 15-50mL PO Qday - BID
  • max 60mL/day

Pediatric Dosing

portal systemic encephalopathy

• infants
  • 2.5-10ml/day PO divided TID-QID
  • titrate for 2-3 soft stools per day

• children
  • 40-90ml/day PO divided TID-QID
  • titrate for 2-3 soft stools per day

Special Populations

• Pregnancy Rating:
• Lactation risk:
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action: