Neuroblastoma (peds)

Background

• Arises from primitive ganglion cells of sympathetic nervous system
• Most common neoplasm in 1st yr of life
• May arise anywhere along sympathetic nervous system
  • Adrenal gland (40%)
  • Abdomen (25%)
  • Chest (15%)

Diagnosis

• Depends on location
  • Large, painless abdominal mass
  • Compression of bowel/bladder
  • Horner syndrome
  • Spinal cord compression
• Opsoclonus-myoclonus
  • Highly a/w neuroblastoma
• Neutropenia/pancytopenia suggests bone marrow involvement

Work-Up

• CXR

Treatment

• Admssion for tumor biopsy

Source

Tintinalli