Intravascular hemolytic tranfusion reaction

Background

• Occurs due to ABO incompatibility

Clinical Features

• Back pain, headache, hypotension, dyspnea, pulmonary edema, bleeding, renal failure

Differential Diagnosis

Transfusion Reaction Types

• Acute
  • Intravascular hemolytic tranfusion reaction
  • Febrile nonhemolytic tranfusion reaction
  • Allergic tranfusion reaction
  • Transfusion-associated circulatory overload (TACO)
  • Transfusion-related acute lung injury (TRALI)
  • Transfusion-associated graft-versus-host disease
  • Fluid overload
  • Sepsis
• Delayed
  • Extravascular hemolytic tranfusion reaction
  • Graft-vs-host disease
  • Transfusion infections

Diagnosis

• Labs consistent with hemolysis

Management

• Stop transfusion
• Replace all tubing
  • Risk of death is proportional to amount of incompatible blood received
• Maintain urine output with IVF (1-2 mL/kg/hr), mannitol, and furosemide as needed
• Treat shock with volume and vasopressors
• Treat coagulopathy with FFP

See Also

• Transfusion reaction