Template:Acute cystitis antibiotics

Outpatient

Women, Uncomplicated

• Nitrofurantoin ER 100mg BID x 5d, OR
• TMP/SMX DS (160/800mg) 1 tab BID x 3d, OR
• Cephalexin 250mg QID x 5d, OR
• Ciprofloxacin 250mg BID x3d
  • Avoid using fluoroquinolone for the first-line treatment of uncomplicated urinary tract infections (UTIs) in women.

Women, Complicated

• Ciprofloxacin 500mg BID x10-14d, OR
• Cefpodoxime 200 mg BID x10-14d

Women, Concern for Urethritis

• Ceftriaxone 250mg IM x1 AND azithromycin 1gm PO x1 AND nitrofurantoin ER 100mg BID x5d, OR
• Levofloxacin 500mg QD x 14d (covers urinary pathogens, GC, and chlamydia)
  • GC resistance to fluoroquinolones is increasing

Men

• Ciprofloxacin 500mg BID x10-14d, OR
• Cefpodoxime 200 mg BID x10-14d

Inpatient Options

• Ciprofloxacin 400mg IV q12hr, OR
• Ceftriaxone 1gm IV QD, OR
• Cefotaxime 1-2gm IV q8hr, OR
• Gentamicin 3mg/kg/day divided q8hr +/- ampicillin 1–2 gm q4hr, OR
• Piperacillin/Tazobactam 3.375 gm IV q6hr, OR
• Cefepime 2gm IV q8hr, OR
• Imipenem 500mg IV q8hr