Labetalol

Adult Dosing

  • Bolus dosing
    • 20mg IV followed by 40-80mg q10min up to total of 300mg
  • Infusion dosing
    • 0.5-2mg/min

Indications

  • HTN in setting of myocardial ischemia
  • HTN in setting of neurologic injury
  • HTN in setting of preeclampsia/eclampsia

Mechanism of Action

  • Class II - Nonselective beta blocker
  • Alpha1 blocker

Adverse Drug Rxns

  • Orthostatic hypotension

Kinetics

  • Onset of action = 2-5min (IV)
  • Duration of action = 2-4hr (IV)

See Also

Antiarrhythmics

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