Ventilation (Strategies)

Inclusion criteria:

ARDS defined as PaO2/FiO2 ratio <300, bilateral alveolar infiltrates on CXR, no evidence of CHF

Treatment:

1) TV 6cc/kg ideal body weight

2) Increased PEEP with decreased FiO2-->

FiO2 (PEEP)

0.4 (5-8)

0.5 (8-10)

0.6 (10)

0.7 (10-14)

0.8 (14)

0.9 (14-18)

1.0 (18-24)

Adjust to:

1) pH = 7.3-7.45 adjust rate (6-35) prn

2) PaO2 = 55-80 (or SaO2 = 88-95%)

Outcome: decreased mortality & #days on the ventilator

2/2/06 DONALDSON (adapted from Lampe; NEJM May 200?)

Authors: