Antipsychotic toxicity

Revision as of 20:27, 1 January 2012 by Jswartz (talk | contribs) (Created page with "==Background== *Toxicity results in blockade of some or all of the following receptors: **Dopamine - extrapyramidal symptoms **Alpha1 - orthostatic hypotension, reflex tachycardi...")
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

Background

  • Toxicity results in blockade of some or all of the following receptors:
    • Dopamine - extrapyramidal symptoms
    • Alpha1 - orthostatic hypotension, reflex tachycardia
    • Muscarinic - anticholinergic symptoms
    • Histamine - sedation


Clinical Features

  1. Extrapyramidal
    1. Acute dystonia
      1. Tongue protrusion, facial grimacing, trismus, oculogyric crisis
    2. Akathisia


Treatment

  1. Extrapyramidal
    1. Diphenhydramine 25-50mg IV/IM OR benztropine 1-2mg IV/IM
    2. Oral therapy with either of above meds should be continued for 2 weeks


See Also

Source

  • Tintinalli
Retrieved from "https://www.wikem.org/w/index.php?title=Antipsychotic_toxicity&oldid=7348"