Colchicine

Administration

• Type: Antigout
• Dosage Forms: Capsules, Tablets
• Routes of Administration: Oral
• Common Trade Names: Colcris; Mitigare (US), Jamp-Colchicine; PMS-Colchicine (Canadian)

Adult Dosing

Gout

• • Flare treatment: Initial: 1.2 mg and then 0.6 mg in an hour (maximum 1.8 mg within 1 hour). In patient receiving prophylaxis treatment wait for 12 h after flare dosing before resuming prophylaxis dose. Do not repeat treatment for at least 3 days (Canadian labelling recommendation)
  • Prophylaxis Treatment: 0.6 mg twice daily (maximum 1.2 mg/day) for 3 months (without tophi) to 6 months (≥1 tophi) after reaching target serum uric acid levels
• Familial Mediterranean Fever (FMF): 1.2 mg to 2.4 mg per day in 1-2 decided dose. Titrate (increase or decrease) 0.3 mg daily increment based on efficacy and adverse effects.

Pediatric Dosing

• Familial Mediterranean Fever (FMF):
  • Children 4 to 6 years: 0.3 to 1.8 mg daily in 1-2 divided doses
  • Children 6 to 12 years: 0.9 to 1.8 mg daily in 1-2 divided doses
  • Adolescents >12 years: Adult dosing
• Gout prophylaxis/treatment: Adult dosing

Special Populations

• Pregnancy Rating:
• Lactation risk:

Renal Dosing

• Adult:
• Pediatric:

Hepatic Dosing

• Adult:
• Pediatric:

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life:
• Metabolism:
• Excretion: