Carbamazepine toxicity
Revision as of 20:12, 25 June 2016 by Neil.m.young (talk | contribs) (Text replacement - "==Source==" to "==References== <references/>")
Background
- Has anticholinergic and antiepileptic effects
- Therapeutic concentration: 4-12
Clinical Features
- May be delayed and follow crescendo-decrescendo course (due to delayed GI motility)
- CNS
- Ataxia
- Nystagmus
- Coma
- Anticholinergic Toxicity
- CV
- Dysrhythmias are rare but may occur
- Wide QRS
- QT Prolongation
Diagnosis
- Levels do not accurately correlate w/ clinical severity
Treatment
- GI detox
- Activated Charcoal (if presents w/in 1hr of ingestion)
- Dialysis is effective (if needed)
Disposition
- Consider discharge for pt with decreasing levels (measured few hrs apart) and is asymptomatic
References
- Tintinalli