Pyrimethamine

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Note: As of 2015, pyrimethamine is only available in the US through a special pharmacy program[1]

Administration

  • Type: Antiparasitic, indicated for treatment and prophylaxis of Toxoplasmosis and malaria
  • Dosage Forms:
  • Routes of Administration: Oral
  • Common Trade Names:

Adult Dosing

  • 25-200mg PO (weekly or daily, depending on indication), in combination with other antimicrobials

Pediatric Dosing

  • 1-3mg/kg PO

Special Populations

Contraindications

  • Allergy to class/drug
  • megaloblastic anemia due to folate deficiency

Adverse Reactions

Serious

  • SJS, TEN
  • Pancytopenia, leukopenia, thrombocytopenia, megaloblastic anemia

Common

  • Rash

Pharmacology

  • Half-life: 52-97 hours
  • Metabolism: Hepatic
  • Excretion:

Mechanism of Action

  • Blocks protozoal dihydrofolate reductase, inhibiting nucleic acid synthesis

Comments

See Also

References

  1. ↑ https://aidsinfo.nih.gov/news/1604/notice-of-availability-of-pyrimethamine
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