Acute myeloid leukemia

Revision as of 19:51, 11 May 2015 by Rossdonaldson1 (talk | contribs) (Created page with "== Background == *aka Acute myelogenous leukemia or non-lymphocytic leukemia *Most common acute leukemia in adults (around 80% of cases) *65yo median age of diagnosis, Male...")
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

Background

  • aka Acute myelogenous leukemia or non-lymphocytic leukemia
  • Most common acute leukemia in adults (around 80% of cases)
  • 65yo median age of diagnosis, Male:Female 5:3
  • characterized by clonal proliferation of myeloid precursors(blast cells >20% in the periphery)

Clinical Features

  • Presents with anemia, neutropenia, thrombocytopenia,
  • weakness, easy fatigability, infections, gingival bleeding/enlargement, ecchymoses, epistaxis, menorrhagia

Differential Diagnosis

Diagnosis

  • CXR
  • CBC with peripheral smear
  • Chem7, ca, mg, phos, Uric Acid, UA, LDH (to check for Tumor Lysis)
  • LFTs, Coags, FDP, D-Dimer, Haptoglobin, Fibrinogen (to check for DIC)
  • Get extra purple top for flow cytometry, especially before transfusion

Treatment

See Also

References