Acute respiratory distress syndrome: Difference between revisions

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***Then 0.25mg/kg/day from day 22-25
***Then 0.25mg/kg/day from day 22-25
***Finally 0.125mg/kg/day from day 26-28
***Finally 0.125mg/kg/day from day 26-28
*[[Ventilation (Main)|Ventilator Settings]]
 
**Permissive hypercapnia
===[[Ventilation (Main)|Ventilator Settings]]===
**Tidal volume 6-8cc/kg of [http://www.mdcalc.com/ideal-body-weight/ predicted body weight]<ref>Brower RG, et al. "Ventilation With Lower Tidal Volumes As Compared With Traditional Tidal Volumes For Acute Lung Injury And The Acute Respiratory Distress Syndrome". The New England Journal of Medicine. 2000. 342(18):1301-1308.</ref>
*Permissive hypercapnia
***Limit barotrauma to healthy area of lung
*Tidal volume 6-8cc/kg of [http://www.mdcalc.com/ideal-body-weight/ predicted body weight]<ref>Brower RG, et al. "Ventilation With Lower Tidal Volumes As Compared With Traditional Tidal Volumes For Acute Lung Injury And The Acute Respiratory Distress Syndrome". The New England Journal of Medicine. 2000. 342(18):1301-1308.</ref>
***Increase PEEP to improve oxygenation
**Limit barotrauma to healthy area of lung
****High FiO2 can cause absorptive atelectasis<ref>O'Brien J. Absorption Atelectasis: Incidence and Clinical Implications. AANA Journal. June 2013. Vol. 81, No. 3.</ref>
**Increase PEEP to improve oxygenation
****Ardsnet PEEP/FiO2 [http://www.ardsnet.org/files/ventilator_protocol_2008-07.pdf protocol card]<ref>Kallet RH, et al. "Respiratory controversies in the critical care setting. Do the NIH ARDS Clinical Trials Network PEEP/FIO2 tables provide the best evidence-based guide to balancing PEEP and FIO2 settings in adults?" Respiratory Care. 2007. 52(4):461-75.</ref>
***High FiO2 can cause absorptive atelectasis<ref>O'Brien J. Absorption Atelectasis: Incidence and Clinical Implications. AANA Journal. June 2013. Vol. 81, No. 3.</ref>
**Maintain plateau pressures < 30 <ref>Hansen-Flaschen et al. Acute respiratory distress syndrome: Clinical features and diagnosis.UpToDate accessed 3/26/14</ref>
***Ardsnet PEEP/FiO2 [http://www.ardsnet.org/files/ventilator_protocol_2008-07.pdf protocol card]<ref>Kallet RH, et al. "Respiratory controversies in the critical care setting. Do the NIH ARDS Clinical Trials Network PEEP/FIO2 tables provide the best evidence-based guide to balancing PEEP and FIO2 settings in adults?" Respiratory Care. 2007. 52(4):461-75.</ref>
**Ensure adequate [[sedation]]
*Maintain plateau pressures < 30 <ref>Hansen-Flaschen et al. Acute respiratory distress syndrome: Clinical features and diagnosis.UpToDate accessed 3/26/14</ref>
***Better synchrony with vent
*Ensure adequate [[sedation]]
***Decreased oxygen consumption
**Better synchrony with vent
***Less [[delirium]]
**Decreased oxygen consumption
***Increased patient comfort
**Less [[delirium]]
**Prone ventilation <ref>Guerin, C. (2014) ‘Prone ventilation in acute respiratory distress syndrome’, European Respiratory Review, 23(132), pp. 249–257.</ref>  
**Increased patient comfort
***Increases survival for severe ARDS
*Prone ventilation <ref>Guerin, C. (2014) ‘Prone ventilation in acute respiratory distress syndrome’, European Respiratory Review, 23(132), pp. 249–257.</ref>  
***Consider for refractory hypoxemia
**Increases survival for severe ARDS
***Many consider this a type of [[recruitment maneuver]]
**Consider for refractory hypoxemia
**[[APRV]] ([[BiVent]]) to recruit alveoli, if minimal to no respiratory acidosis<ref>CritCareMed. 2005;33:S228 Other Approaches to Open-Lung Ventilation–Airway Pressure Release Ventilation.</ref><ref>CleveClinJMed 2011;78:101 Airway Pressure Release Ventilation–Alternative Mode of Mechanical Ventilation in Acute Respiratory Distress Syndrome.</ref>
**Many consider this a type of [[recruitment maneuver]]
***Start PHigh at PPlat at 28, try not to go beyond 35 cmH2O
*[[APRV]] ([[BiVent]]) to recruit alveoli, if minimal to no respiratory acidosis<ref>CritCareMed. 2005;33:S228 Other Approaches to Open-Lung Ventilation–Airway Pressure Release Ventilation.</ref><ref>CleveClinJMed 2011;78:101 Airway Pressure Release Ventilation–Alternative Mode of Mechanical Ventilation in Acute Respiratory Distress Syndrome.</ref>
***PPlateau = desired Pmean + 3 cmH2O
**Start PHigh at PPlat at 28, try not to go beyond 35 cmH2O
***PLow at 0 cmH2O for maximal expiration
**PPlateau = desired Pmean + 3 cmH2O
***THigh at 4.5-6 seconds (inspiratory time)
**PLow at 0 cmH2O for maximal expiration
***Tlow at 0.5-0.8 seconds (expiratory time), with TV 4-6 cc/kg
**THigh at 4.5-6 seconds (inspiratory time)
***[[Automatic tube compensation]] ON if patient spontaneously breathing<ref>Guttmann J et al. Automatic tube compensation (ATC). Minerva Anestesiol. 2002 May;68(5):369-77.</ref>
**Tlow at 0.5-0.8 seconds (expiratory time), with TV 4-6 cc/kg
***Full benefit of APRV is in patients that are not paralyzed that can provide spontaneous breaths
**[[Automatic tube compensation]] ON if patient spontaneously breathing<ref>Guttmann J et al. Automatic tube compensation (ATC). Minerva Anestesiol. 2002 May;68(5):369-77.</ref>
***Wean by "dropping and stretching"
**Full benefit of APRV is in patients that are not paralyzed that can provide spontaneous breaths
****Every two hours or as tolerated, decrease PHigh by 1-2 cmH2O and increasing THight by 0.5 seconds per 1 cmH2O drop in PHigh
**Wean by "dropping and stretching"
****Monitor for drop in SpO2, increased work of breathing, tachypnea
***Every two hours or as tolerated, decrease PHigh by 1-2 cmH2O and increasing THight by 0.5 seconds per 1 cmH2O drop in PHigh
****Once PHigh reaches 10 cmH2O and THigh resaches 12-15 seconds with spontaneous respirations, change mode to CPAP with PEEP 10 cmH2O and PS 5-10 cmH2O, turn ATC off
***Monitor for drop in SpO2, increased work of breathing, tachypnea
**[[Pressure control ventilation]] ([[PCV]]) if acidosis with APRV
***Once PHigh reaches 10 cmH2O and THigh resaches 12-15 seconds with spontaneous respirations, change mode to CPAP with PEEP 10 cmH2O and PS 5-10 cmH2O, turn ATC off
***Attempt to maintain same rate
*[[Pressure control ventilation]] ([[PCV]]) if acidosis with APRV
***Maintain same Pmean
**Attempt to maintain same rate
**[[PRVC]] or [[Volume control ventilation]] with paralysis to prevent barotrauma in breath stacking and vent dyssynchrony<ref>Gainnier M, Roch A, Forel JM, et al. Effect of neuromuscular blocking agents on gas exchange in patients presenting with acute respiratory distress syndrome. Crit Care Med. 2004;32:113-119.</ref><ref>Papazian L, Forel JM, Gacouin A, et al. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med. 2010;363:1107-1116.</ref>
**Maintain same Pmean
***[[Cisatricurium]] loading dose 0.15 mg/kg, followed by 1-3 mcg/kg/min
*[[PRVC]] or [[Volume control ventilation]] with paralysis to prevent barotrauma in breath stacking and vent dyssynchrony<ref>Gainnier M, Roch A, Forel JM, et al. Effect of neuromuscular blocking agents on gas exchange in patients presenting with acute respiratory distress syndrome. Crit Care Med. 2004;32:113-119.</ref><ref>Papazian L, Forel JM, Gacouin A, et al. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med. 2010;363:1107-1116.</ref>
***Titrated to less than 2 twitches in train of four
**[[Cisatricurium]] loading dose 0.15 mg/kg, followed by 1-3 mcg/kg/min
***Cisatricurium preferred to pancuronium in renal impairment
**Titrated to less than 2 twitches in train of four
***Cannot use paralysis with APRV
**Cisatricurium preferred to pancuronium in renal impairment
**[[Recruitment maneuver]]
**Cannot use paralysis with APRV
***Varying methods and protocols
*[[Recruitment maneuver]]
***Controversial in risks and benefits
**Varying methods and protocols
**Controversial in risks and benefits


===Adjuncts===
===Adjuncts===

Revision as of 12:17, 21 March 2020

Background

  • Non-cardiogenic pulmonary edema due to lung capillary endothelial injury (diffuse alveolar damage)
    • Proteinaceous material accumulate in alveoli in a heterogeneous manner (hyalinosis)
  • Symptom of an underlying disease

Clinical Features

Diagnostic Criteria[1]

  1. New onset respiratory symptoms
  2. Bilateral pulmonary opacities
  3. Symptoms not explained by cardiac etiology or volume overload

Severity by Berlin Definition[1]

PaO2/FiO2 Severity Mortality
200-300 Mild 27%
100-200 Mod 32%
<100 Severe 45%

Presentation

Imaging

  • Diffuse patchy pulmonary infiltrates

Causes

Differential Diagnosis

Pulmonary Edema Types

Pulmonary capillary wedge pressure <18 mmHg differentiates noncardiogenic from cardiogenic pulmonary edema[2]

Evaluation

ARDS on CXR

Management

  • Treat underlying cause
  • Supplemental O2
  • Noninvasive ventilation
    • Limited data to support use
  • Consider pulse dose steroids in early, established, severe ARDS in ICU setting[4]
    • NOT for prevention of ARDS (will increase risk for ARDS and worsening sepsis if not in ARDS already)
    • In theory, may reduce fibro-proliferative inflammatory changes during exudative phase (< 1 wk)
    • No benefit to starting in late ARDS (> 2 wks)
    • Meduri protocol (21 vs. 43% mortality)[5]
      • 1mg/kg loading dose methylprednisolone
      • Followed by infusion of 1mg/kg/day from day 1-14
      • Then 0.5mg/kg/day from day 15-21
      • Then 0.25mg/kg/day from day 22-25
      • Finally 0.125mg/kg/day from day 26-28

Ventilator Settings

  • Permissive hypercapnia
  • Tidal volume 6-8cc/kg of predicted body weight[6]
    • Limit barotrauma to healthy area of lung
    • Increase PEEP to improve oxygenation
  • Maintain plateau pressures < 30 [9]
  • Ensure adequate sedation
    • Better synchrony with vent
    • Decreased oxygen consumption
    • Less delirium
    • Increased patient comfort
  • Prone ventilation [10]
    • Increases survival for severe ARDS
    • Consider for refractory hypoxemia
    • Many consider this a type of recruitment maneuver
  • APRV (BiVent) to recruit alveoli, if minimal to no respiratory acidosis[11][12]
    • Start PHigh at PPlat at 28, try not to go beyond 35 cmH2O
    • PPlateau = desired Pmean + 3 cmH2O
    • PLow at 0 cmH2O for maximal expiration
    • THigh at 4.5-6 seconds (inspiratory time)
    • Tlow at 0.5-0.8 seconds (expiratory time), with TV 4-6 cc/kg
    • Automatic tube compensation ON if patient spontaneously breathing[13]
    • Full benefit of APRV is in patients that are not paralyzed that can provide spontaneous breaths
    • Wean by "dropping and stretching"
      • Every two hours or as tolerated, decrease PHigh by 1-2 cmH2O and increasing THight by 0.5 seconds per 1 cmH2O drop in PHigh
      • Monitor for drop in SpO2, increased work of breathing, tachypnea
      • Once PHigh reaches 10 cmH2O and THigh resaches 12-15 seconds with spontaneous respirations, change mode to CPAP with PEEP 10 cmH2O and PS 5-10 cmH2O, turn ATC off
  • Pressure control ventilation (PCV) if acidosis with APRV
    • Attempt to maintain same rate
    • Maintain same Pmean
  • PRVC or Volume control ventilation with paralysis to prevent barotrauma in breath stacking and vent dyssynchrony[14][15]
    • Cisatricurium loading dose 0.15 mg/kg, followed by 1-3 mcg/kg/min
    • Titrated to less than 2 twitches in train of four
    • Cisatricurium preferred to pancuronium in renal impairment
    • Cannot use paralysis with APRV
  • Recruitment maneuver
    • Varying methods and protocols
    • Controversial in risks and benefits

Adjuncts

Disposition

  • Admit to ICU

See Also

External Links

ARDSnet Ventilator Settings

References

  1. 1.0 1.1 Ferguson ND et. al. The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med. 2012 Oct;38(10):1573-82.
  2. Clark SB, Soos MP. Noncardiogenic Pulmonary Edema. In: StatPearls. Treasure Island (FL): StatPearls Publishing; October 1, 2020.
  3. http://www.cdc.gov/flu/professionals/antivirals/summary-clinicians.htm
  4. Khilnani GC and Hadda V. Corticosteroids and ARDS: A review of treatment and prevention evidence. Lung India. 2011 Apr-Jun; 28(2): 114–119.
  5. Meduri GU, Golden E, Freire AX, Taylor E, Zaman M, Carson SJ, et al. Methylprednisolone infusion in early severe ARDS: Results of a randomized controlled trial. Chest. 2007;131:954–63.
  6. Brower RG, et al. "Ventilation With Lower Tidal Volumes As Compared With Traditional Tidal Volumes For Acute Lung Injury And The Acute Respiratory Distress Syndrome". The New England Journal of Medicine. 2000. 342(18):1301-1308.
  7. O'Brien J. Absorption Atelectasis: Incidence and Clinical Implications. AANA Journal. June 2013. Vol. 81, No. 3.
  8. Kallet RH, et al. "Respiratory controversies in the critical care setting. Do the NIH ARDS Clinical Trials Network PEEP/FIO2 tables provide the best evidence-based guide to balancing PEEP and FIO2 settings in adults?" Respiratory Care. 2007. 52(4):461-75.
  9. Hansen-Flaschen et al. Acute respiratory distress syndrome: Clinical features and diagnosis.UpToDate accessed 3/26/14
  10. Guerin, C. (2014) ‘Prone ventilation in acute respiratory distress syndrome’, European Respiratory Review, 23(132), pp. 249–257.
  11. CritCareMed. 2005;33:S228 Other Approaches to Open-Lung Ventilation–Airway Pressure Release Ventilation.
  12. CleveClinJMed 2011;78:101 Airway Pressure Release Ventilation–Alternative Mode of Mechanical Ventilation in Acute Respiratory Distress Syndrome.
  13. Guttmann J et al. Automatic tube compensation (ATC). Minerva Anestesiol. 2002 May;68(5):369-77.
  14. Gainnier M, Roch A, Forel JM, et al. Effect of neuromuscular blocking agents on gas exchange in patients presenting with acute respiratory distress syndrome. Crit Care Med. 2004;32:113-119.
  15. Papazian L, Forel JM, Gacouin A, et al. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med. 2010;363:1107-1116.