Difference between revisions of "Acute transfusion reaction"

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== Acute ==
== Acute ==
===Febrile Nonhemolytic Tranfusion Reaction===
*Occurs in 20% of pts due to recipient Ab against donor leukocytes
**Fever, HA, myalgias, tachycardia, dyspnea, chest pain
**Stop tranfusion pending rule-out of hemolytic transfusion reaction
**Give antipyretic
**Restart transfusion once hemolytic transfusion reaction is ruled-out
===Allergic Tranfusion Reaction===
===Allergic Tranfusion Reaction===
*Occurs due to immune response to plasma proteins
*Occurs due to immune response to plasma proteins

Revision as of 20:49, 4 February 2016


Transfusion Risk Ratios[1]

Rate Complication
1:10 Febrile non-hemolytic transfusion reaction per pool of 5 donor units of platelets (1 pack)
1:100 Minor allergic reactions (urticaria)
1:300 Febrile non-hemolytic transfusion reaction per unit of RBC (1 pack)
1:700 Transfusion-associated circulatory overload per transfusion episode
1:5,000 Transfusion-related acute lung injury (TRALI)
1:7,000 Delayed hemolytic transfusion reaction
1:10,000 Symptomatic bacterial sepsis per pool of 5 donor units of platelets
1:40,000 Death from bacterial sepsis per pool of 5 donor units of platelets
1:40,000 ABO-incompatible transfusion per RBC transfusion episode
1:40,000 Serious allergic reaction per unit of component
1:82,000 Transmission of hepatitis B virus per unit of component
1:100,000 Symptomatic bacterial sepsis per unit of RBC
1:500,000 Death from bacterial sepsis per unit of RBC
1:1,000,000 Transmission of West Nile Virus
1:3,000,000 Transmission of HTLV per unit of component
1:3,100,000 Transmission of hepatitis C virus per unit of component
1:4,700,000 Transmission of HIV per unit of component

Differential Diagnosis

Transfusion Reaction Types


Allergic Tranfusion Reaction

  • Occurs due to immune response to plasma proteins
  • Diagnosis
    • Symptoms range from urticaria/pruritus to bronchospasm, wheezing, anaphylaxis (rare)
  • Treatment
    • Stop transfusion until able to evaluate severity of allergic reaction
    • Give diphenhydramine
    • Restart transfusion if symptoms are mild

Transfusion-associated circulatory overload (TACO)

  • Often confused with TRALI
  • Frequently with rapid admin and large volume transfusions
  • Associated with a rapid rise in blood pressure, not hypotension
  • Diagnosis
    • Dyspnea, orthopnea, peripheral edema, rapid rise in BP
    • BNP or NT-proBNP to differentiate from other lung injury
  • Treatment
    • O2, supportive care, diuretics

Transfusion-Related Acute Lung Injury (TRALI)

  • Due to granulocyte recruitment and degranulation within the lung
  • More common with FFP and plt transfusions (extremely rare with pRBC transfusion alone)
    • pRBCs do contain residual plasma and can have TRALI
  • Time Frame: abrupt to within 6 hours of transfusion initiation
  • Diagnosis
    • ARDS-like symptoms
    • B/l pulmonary infiltrates due to noncardiogenic pulmonary edema w/in 6h of transfusion
  • Treatment
    • Strop transfusion
    • Treat like ARDS
    • Avoid diuresis
Onset Acute, within 6hrs Often more gradual
BP Low High
Temp Febrile Normal
JVD/pedal edema Unlikely Likely
CVP/PAWP Normal Elevated
BNP Normal Elevated
Resp Dyspneic Dyspneic
CXR B/l infiltrates B/l infiltrates

Fluid Overload

  • Split pRBCs to tranfuse more slowly (as slow as 1mL/kg/hr)


  • Most commonly due to yersinia which is able to grow easily in refrigerated blood


Extravascular hemolytic tranfusion reaction

Graft-vs-host disease

Differential Diagnosis

Acute allergic reaction


  • For all reactions:
    • Stop the transfusion (at least temporarily)
    • Call the blood bank
    • Draw a new type + screen

See Also


  • Canadian Blood Services (Public Health Agency of Canada)
  1. Wagner, L. Why Should Clinicians Be Concerned about Blood Conservation? ITACCS. 2005 PDF