Acute transfusion reaction

Revision as of 20:09, 12 May 2011 by Jswartz (talk | contribs)

Acute

  1. Intravascular Hemolytic TR
    1. ABO incompatability --> serious
    2. Sx: fever/ch/joint or back pain/shock
    3. Tx: stop, fluids+lasix, re-check blood
  2. Febrile TR
    1. anitbodies --> mild
    2. Sx: fever/ch/malaise
    3. Tx: R/O above
  3. Allergic
    1. Tx as allergic Rx --> range
  4. Transfusion-Related Acute Lung Injury (TRALI)
    1. Sx: acute ARDS-like injury --> severe
    2. Tx: stop trans, Tx as ARDS
  5. Sepsis (Bacterial Contamination)
  6. Fluid Overload

Delayed

  1. Extravascular Hemolytic TR
    1. days-weeks after --> mild
    2. Sx: fever/anemia/jaundice
    3. Tx: none
  2. Graft-vs-Host
    1. in leukemia/lymphoma pt if given trans after chemo (use leuk-poor components)
    2. Sx: fever/rash/n/v/inc LFTs/pancytopenia --> severe
    3. Tx: no effective Tx --> death
  3. Hemosiderosis

Source

2/18/06 DONALDSON (adapted from Rosen)