Acute transfusion reaction

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Acute

1) Intravascular Hemolytic TR

-ABO inconpatability --> serious

-Sx: fever/ch/joint or back pain/shock

-Tx: stop, fluids+lasix, re-check blood

2) Febrile TR

-anitbodies --> mild

-Sx: fever/ch/malaise

-Tx: R/O above

3) Allergic

-Tx as allergic Rx --> range

4) Transfusion-Related Acute Lung Injury (TRALI)

-Sx: acute ARDS-like injury --> severe

-Tx: stop trans, Tx as ARDS

5) Sepsis (Bacterial Contamination)

6) Fluid Overload


Delayed

1) Extravascular Hemolytic TR

-days-weeks after --> mild

-Sx: fever/anemia/jaundice

-Tx: none

2) Graft-vs-Host

-in leukemia/lymphoma pt if given trans after chemo (use leuk-poor components)

-Sx: fever/rash/n/v/inc LFTs/pancytopenia --> severe

-Tx: no effective Tx --> death

3) Hemosiderosis


Source

2/18/06 DONALDSON (adapted from Rosen)