Aminoglycosides

Background

• Used (alone or with beta-lactam) to treat serious infections due to gram-negative bacilli, e.g.:
  • Ill patient with pyelonephritis
  • Meningitis (due to pseudomonas, acinetobacter)
  • Peritoneal dialysis-associated peritonitis
  • Bacterial endocarditis
• Used +/- beta-lactam
• Nephro and oto toxic. Risk of neuromuscular blockade.
• Can precipitate crisis in patients with myasthenia gravis
• Include gentamicin and tobramycin

See Also

• Antibiotics (Main)

References

Goodman & Gilman's Pharmacology