Difference between revisions of "Angioedema"

(Text replacement - " pts" to " patients")
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==Background==
 
==Background==
 
*Angioedema is paroxysmal, nondemarcated swelling of dermal or submucosal layers of skin or mucosa
 
*Angioedema is paroxysmal, nondemarcated swelling of dermal or submucosal layers of skin or mucosa
**Swelling is asymmetric, nonpitting, and nonpruritic
+
**Swelling is asymmetric, nonpitting, and nonpruritic, however can be associated with allergic features depending on cause
  
 
===Etiologies===
 
===Etiologies===
 
*Congenital or acquired loss of C1 esterase inhibitor
 
*Congenital or acquired loss of C1 esterase inhibitor
*IgE–mediated type I [[Hypersensitivity Reaction|hypersensitivity reaction]]
+
*IgE–mediated type I [[Hypersensitivity Reaction|hypersensitivity reaction]] ([[Allergic reaction]])
*ACEI adverse reaction (excessive bradykinin)
+
*ACEI adverse reaction from excessive bradykinin
 
*Idiopathic
 
*Idiopathic
  

Revision as of 17:25, 1 July 2016

Background

  • Angioedema is paroxysmal, nondemarcated swelling of dermal or submucosal layers of skin or mucosa
    • Swelling is asymmetric, nonpitting, and nonpruritic, however can be associated with allergic features depending on cause

Etiologies

Angioedema
Angioedema of tongue

Hereditary angioedema

Background

  • Due to C1 esterase inhibitor deficiency
    • Leads to unregulated activity of vasoactive mediators (bradykinin) associated with complement pathway
    • Autosomal dominant
  • Edema of face, extremities, bowel wall

Diagnosis

  • Suspect in patients with history of recurrent peripheral angioedema and abdominal pain
    • 75% experience onset of symptoms before age 15yr
  • C4 level screens for HAE (suspect if low)
  • Decreased levels of C1 and C4 esterase inhibitors confirms diagnosis

Treatment

  • Strongly consider definitive airway if voice change, hoarseness, stridor, dyspnea - arrange transfer to OR if not crashing
  • Epinephrine can produce some improvement in early acute attacks associated with anaphylaxis, however, HAE is bradykinin mediated and the role of steroids and H1/H2 blockers is limited
  • If available - C1 esterase inhibitors (Berinert 20u/kg IV), kallikrein/bradykinin inhibitors (ecallantide 30mg SQ), or bradykinin receptor antagonist (icantibant 30mg SQ)
  • FFP
    • Replaces the missing inhibitor protein
    • Not recommended in life-threatening laryngeal edema (some patients may become more edematous)
      • Instead, pt should undergo fiberoptic intubation w/ preparation for surgical airway

ACE inhibitor-induced angioedema

Background

  • Incidence is highest within the first month; however, may occur at anytime
  • 40% present months to years after initial dose[1]
  • Incidence is 0.1-2.2% (more common in blacks)
  • Physiology more closely related to bradykinin-mediated pathway than IgE-mediated pathway, therefore current treatments may be insufficient

Treatment

  • Airway management as above, consider awake fiberoptic intubation
  • Epinephrine 0.3mg IM q15-20min prn
  • Consider glucagon 1-5mg IV if pt on B-blockers and not responding to epi
  • Diphenhydramine 50mg IV OR cetirizine 10mg PO
  • Methylprednisolone 125mg IV
  • H2 blocker IV or PO

Differential Diagnosis

Acute allergic reaction

Disposition

  • Consider discharge after 4-6 hrs obs if there is no airway edema and pt improves
  • 24 hrs obs if epi given
  • Ishoo Staging (based on retrospective study)[2]
    • Stage 1 - face/lip
      • 48% outpatient, 52% floor, 0% ICU or advanced airway
    • Stage 2 - soft palate
      • 60% outpt, 40% floor, 0 ICU or advanced airway
    • Stage 3 - tongue
      • 26% outpt, 67% ICU, 7% advanced airway
    • Stage 4 - larynx
      • 100% ICU, 24% advanced airway

See Also

References

  1. Winters ME, et al. Emergency department management of patients with ACE-inhibitor angioedema. JEM. 2013; 45(5):775–780.
  2. Ishoo E, et al. Predicting airway risk in angioedema: staging system based on presentation. Otolaryngol Head Neck Surg. 1999; 121(3):263-268.