Baclofen toxicity: Difference between revisions
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*Indications include MS, muscle spasticity pain | *Indications include MS, muscle spasticity pain | ||
*GABAb receptor agonist | *GABAb receptor agonist | ||
*Most excretion is renal | |||
== | ==Clinical Features== | ||
* | *nausea and vomiting | ||
*Drowziness, dizziness | *Drowziness, dizziness | ||
*Seizures, delirium, | *Seizures, delirium, altered mental status, coma | ||
*Bradycardia, hypotension OR | *Bradycardia, hypotension '''OR''' hypertension, respiratory compromise | ||
*Hypothermia | *Hypothermia | ||
==Differential Diagnosis== | |||
==Evaluation== | |||
*Diagnosis of exclusion | |||
==Management== | ==Management== | ||
*Activated charcoal for recent ingestion | *Activated charcoal for recent ingestion | ||
*Supportive care: | *Supportive care: | ||
| Line 17: | Line 23: | ||
**Vasopressors for persistent hypotension | **Vasopressors for persistent hypotension | ||
**Benzodiazepines for seizures | **Benzodiazepines for seizures | ||
*Hemodialysis for very severe toxicity | *[[Hemodialysis/Hemoperfusion|Hemodialysis]] for very severe toxicity | ||
==Disposition== | |||
==See Also== | |||
==References== | ==References== | ||
<References/> | |||
*Jung, M. “Baclofen Overdoses”. Maryland Poison Center, University of Maryland School of Pharmacy. www.mdpoison.com Accessed April 29th, 2014. | *Jung, M. “Baclofen Overdoses”. Maryland Poison Center, University of Maryland School of Pharmacy. www.mdpoison.com Accessed April 29th, 2014. | ||
*Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82 | *Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82 | ||
[[Category:Toxicology]] | |||
Revision as of 23:38, 30 May 2017
Background
- Indications include MS, muscle spasticity pain
- GABAb receptor agonist
- Most excretion is renal
Clinical Features
- nausea and vomiting
- Drowziness, dizziness
- Seizures, delirium, altered mental status, coma
- Bradycardia, hypotension OR hypertension, respiratory compromise
- Hypothermia
Differential Diagnosis
Evaluation
- Diagnosis of exclusion
Management
- Activated charcoal for recent ingestion
- Supportive care:
- IV fluids, respiratory care
- Vasopressors for persistent hypotension
- Benzodiazepines for seizures
- Hemodialysis for very severe toxicity
Disposition
See Also
References
- Jung, M. “Baclofen Overdoses”. Maryland Poison Center, University of Maryland School of Pharmacy. www.mdpoison.com Accessed April 29th, 2014.
- Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82