Baclofen toxicity: Difference between revisions

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==Clinical Features==
==Clinical Features==
*N/V
*nausea and vomiting
*Drowziness, dizziness
*Drowziness, dizziness
*Seizures, delirium, AMS, coma
*Seizures, delirium, altered mental status, coma
*Bradycardia, hypotension OR HTN, respiratory compromise
*Bradycardia, hypotension '''OR''' hypertension, respiratory compromise
*Hypothermia
*Hypothermia


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==Diagnosis==
==Evaluation==
*Diagnosis of exclusion
*Diagnosis of exclusion


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**Vasopressors for persistent hypotension
**Vasopressors for persistent hypotension
**Benzodiazepines for seizures
**Benzodiazepines for seizures
*Hemodialysis for very severe toxicity
*[[Hemodialysis/Hemoperfusion|Hemodialysis]] for very severe toxicity


==Disposition==
==Disposition==
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*Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82
*Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82


[[Category:Tox]]
[[Category:Toxicology]]

Revision as of 23:38, 30 May 2017

Background

  • Indications include MS, muscle spasticity pain
  • GABAb receptor agonist
  • Most excretion is renal

Clinical Features

  • nausea and vomiting
  • Drowziness, dizziness
  • Seizures, delirium, altered mental status, coma
  • Bradycardia, hypotension OR hypertension, respiratory compromise
  • Hypothermia

Differential Diagnosis

Evaluation

  • Diagnosis of exclusion

Management

  • Activated charcoal for recent ingestion
  • Supportive care:
    • IV fluids, respiratory care
    • Vasopressors for persistent hypotension
    • Benzodiazepines for seizures
  • Hemodialysis for very severe toxicity

Disposition

See Also

References

  • Jung, M. “Baclofen Overdoses”. Maryland Poison Center, University of Maryland School of Pharmacy. www.mdpoison.com Accessed April 29th, 2014.
  • Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82