Baclofen toxicity: Difference between revisions
m (Rossdonaldson1 moved page Baclofen Toxicity to Baclofen toxicity) |
(Text replacement - "OR" to "'''OR'''") |
||
(6 intermediate revisions by 4 users not shown) | |||
Line 5: | Line 5: | ||
==Clinical Features== | ==Clinical Features== | ||
* | *nausea and vomiting | ||
*Drowziness, dizziness | *Drowziness, dizziness | ||
*Seizures, delirium, | *Seizures, delirium, altered mental status, coma | ||
*Bradycardia, hypotension OR | *Bradycardia, hypotension '''OR''' hypertension, respiratory compromise | ||
*Hypothermia | *Hypothermia | ||
Line 14: | Line 14: | ||
== | ==Evaluation== | ||
*Diagnosis of exclusion | *Diagnosis of exclusion | ||
Line 23: | Line 23: | ||
**Vasopressors for persistent hypotension | **Vasopressors for persistent hypotension | ||
**Benzodiazepines for seizures | **Benzodiazepines for seizures | ||
*Hemodialysis for very severe toxicity | *[[Hemodialysis/Hemoperfusion|Hemodialysis]] for very severe toxicity | ||
==Disposition== | ==Disposition== | ||
Line 36: | Line 36: | ||
*Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82 | *Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82 | ||
[[Category: | [[Category:Toxicology]] |
Revision as of 23:38, 30 May 2017
Background
- Indications include MS, muscle spasticity pain
- GABAb receptor agonist
- Most excretion is renal
Clinical Features
- nausea and vomiting
- Drowziness, dizziness
- Seizures, delirium, altered mental status, coma
- Bradycardia, hypotension OR hypertension, respiratory compromise
- Hypothermia
Differential Diagnosis
Evaluation
- Diagnosis of exclusion
Management
- Activated charcoal for recent ingestion
- Supportive care:
- IV fluids, respiratory care
- Vasopressors for persistent hypotension
- Benzodiazepines for seizures
- Hemodialysis for very severe toxicity
Disposition
See Also
References
- Jung, M. “Baclofen Overdoses”. Maryland Poison Center, University of Maryland School of Pharmacy. www.mdpoison.com Accessed April 29th, 2014.
- Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82