Difference between revisions of "Barbiturates"

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#REDIRECT[[Barbiturate Toxicity]]
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==Background==
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*Are [[Sedative/hypnotic toxicity|sedative/hypnotics]] used mainly for anesthesia and epilepsy
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==Types==
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{| {{table}}
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| align="center" style="background:#f0f0f0;"|'''Drug'''
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| align="center" style="background:#f0f0f0;"|'''Half-life (h)'''
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| align="center" style="background:#f0f0f0;"|'''Duration of Effect (h)'''
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| align="center" style="background:#f0f0f0;"|'''Hypnotic Dose (mg)'''
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| align="center" style="background:#f0f0f0;"|'''Minimum Toxic level (mg/L)'''
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|-
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| '''Ultra–short-acting'''||||||||
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|-
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| [[Methohexital]]||3-5||< 0.5||50-120||>5
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|-
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| [[Thiopental]]||8-10||< 0.5||50-75||>5
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|-
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| '''Short-acting'''||||||||
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|-
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| [[Secobarbital]]||15-40||>3-4||100-200||>10
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|-
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| '''Intermediate-acting'''||||||||
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|-
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| [[Amobarbital]]||10-40||>4-6||65-200||>10
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|-
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| [[Butabarbital]]||35-50||>4-6||100-200||>10
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|-
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| '''Long-acting'''||||||||
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|-
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| [[Mephobarbital]]||10-70||>6-12||50-100||>30
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|-
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| [[Phenobarbital]]||80-120||>6-12||100-320||>30
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|}
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==See Also==
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*[[Barbituate toxicity]]
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[[Category:Pharmacology]]

Latest revision as of 05:18, 7 July 2016

Background

Types

Drug Half-life (h) Duration of Effect (h) Hypnotic Dose (mg) Minimum Toxic level (mg/L)
Ultra–short-acting
Methohexital 3-5 < 0.5 50-120 >5
Thiopental 8-10 < 0.5 50-75 >5
Short-acting
Secobarbital 15-40 >3-4 100-200 >10
Intermediate-acting
Amobarbital 10-40 >4-6 65-200 >10
Butabarbital 35-50 >4-6 100-200 >10
Long-acting
Mephobarbital 10-70 >6-12 50-100 >30
Phenobarbital 80-120 >6-12 100-320 >30

See Also