Behçet's disease: Difference between revisions

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==Differential Diagnosis==
==Differential Diagnosis==
*[[HSV]]
*[[HSV]]
*[[lichen planus]]
*[[Lichen planus]]
*[[pemphigus vulgaris]]
*[[Pemphigus vulgaris]]
*[[pemphigoid]]
*[[Bullous pemphigoid]]
*IVD
*IVD
*[[SJS]]
*[[SJS]]
*celiac disease
*celiac disease
*[[SLE]]
*[[SLE]]
*[[Sjogren's]]
*[[Sjögren Syndrome]]
*[[MS]]
*[[MS]]
*[[Sarcoidosis]]
*[[Sarcoidosis]]
*[[Syphilis]]
*[[Syphilis]]
*[[TB]]
*[[TB]]
*malignancy
*Malignancy
*[[Reactive arthritis]]
*[[Reactive arthritis]]
*[[HIV]]
*[[HIV]]
*Other [[vasculitis syndromes]]
*Other [[vasculitis]] syndromes


==Evaluation==
==Evaluation==
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*Severe mucocutaneous disease: [[Prednisone]] 1mg/kg, low-dose thalidomide, or methotrexate
*Severe mucocutaneous disease: [[Prednisone]] 1mg/kg, low-dose thalidomide, or methotrexate
*Systemic disease: Steroid +/- [[cyclophosphamide]] or [[azathioprine]]
*Systemic disease: Steroid +/- [[cyclophosphamide]] or [[azathioprine]]
*Ocular: Prednisone + azathioprine and rapid ophthalmologist referral
*Ocular: [[Prednisone]] + [[azathioprine]] and rapid ophthalmologist referral
*Cerebral [[venous sinus thrombosis]]- [[heparin]]
*Cerebral [[venous sinus thrombosis]]- [[heparin]]



Revision as of 23:32, 17 October 2019

Background

Behcet's.png
  • Chronic small-vessel vasculitis
  • Mucocutaneous, ocular, cardiovascular, renal, GI, pulmonary, urologic, musculoskeletal, CNS involvement
  • Aphthous oral ulcers + ≥ 2 of following: Genital aphthae, cutaneous lesions, and neurological, oral or rheumatologic manifestations

Clinical Features

Differential Diagnosis

Evaluation

  • Clinical diagnosis
  • ESR/CRP elevated

Classification

  • International Study Group Criteria
  • Recurrent oral aphthae (at least 3 times in 1 year) + 2 of the following in absence of other systemic diseases:
    • Recurrent genital aphthae
    • Eye lesions
    • Skin lesions
    • A positive pathery test

Management

References

  • Rosen's Emergency Medicine 8th edition. 2013. Chapter: Erythematosus and the Vasculitides. p1540.
  • Smith EL, et al. Clinical manifestations and diagnosis of Behcet's disease. In: Post T, ed. UpToDate. Waltham, Mass.: UpToDate; 2014. www.uptodate.com. Accessed December 22, 2014.
  • Alnaimat FA, et al. (2014, Dec 16). Behcet Disease. eMedicine. Retrieved 12/22/2014 from http://emedicine.medscape.com/article/329099-overview