View source for Brucella

==Background==
*Brucella are gram negative coccobacilli 
*Zoonosis that causes brucellosis (also known as undulant fever, mediterranean fever, or malta fever)
*Facultative intracellular pathogens, live in monocytes and macrophages in lymph nodes, bone marrow, liver and spleen.  
*Several species, including Brucella melitensis (most patholgenic in humans, main hosts are goats/sheep), Brucella abortus, Brucella suis, Brucella canis, Brucella ceti, and Brucella pinnipediae
**Brucella melitensis eradicated in the US since 1970s, but cases still occur, mainly secondary to unpasteurized dairy products from outside the US
**Brucella abortus' main host is cattle, cases occur from wild bison/elk
**Brucella Suis' main host is swine
**Brucella canis' main host is dogs
**Brucella ceti and pinnipediae find hosts in marine species, cause neurobrucellosis
*Death from brucellosis occurs in only 2% of cases (CDC).  

===Transmission===
#Consumption of poorly cooked meat or unpasteurized dairy products (most common mode of transmission).
#Inhalation of bacteria.  Increased in those that work in laboratories that work with the bacteria and slaughterhouse workers.
#Directly via open skin wounds.  
#Rare modes of transmission include via breastmilk, sexual transmission, tissue transplant, blood transfusion.

==Clinical Symptoms==
*Typical syndrome includes acute to sub-acute febrile illness, associated with fatigue, myalgias,joint pain, and headaches.  Patients may also experience hepatomegaly and/or splenomegaly.  Fever may "undulate" over days, which is why some describe the disease as "undulant fever."  Patients may find symptoms are best in the morning and progressively  worsen over the day.  The acute illness can progress to a chronic illness. Incubation is 2-3 weeks but may also be insidious in onset.  
*[[Fever]]
*Diaphoresis
*[[Myalgias]]
*[[Headache]]
*[[Fatigue]]
*Joint/bone pain - occurs in 40% of cases, represented by arthritis, ostemyelitis, bursitis, etc. 
*[[Nausea/vomiting]]
*[[Abdominal pain]]

===Complications===
#Cardiac: [[Endocarditis]] (2% of cases per W.H.O.) with aortic valve>mitral valve involvement.  
#Pulmonary: Hilar lymphadenopathy, pneumonitis, [[pneumonia]], effusions.
#GI: nausea/vomiting, abdominal pain.  
#Liver: liver granulomas, hepatitis, hepatocellular necrosis
#Gallbladder: cholecystitis 
#Neuro: "Neurobrucellosis"causing meningitis/encephalitis, neuro abscess, GBS, peripheral neuroapthy.   
#Bone/joint: tenosynovitis, arthritis, osteomyelitis. 
#Skin: Rashes, abscess.  Rash is nonspecific and can range from erythema nodosum to nodules and petechiae.  
#ophtho: Uveitis, optic neuritis.  
#GU: Epididymitis, orchitis, salpingitis.
#Reproductive: spontaneous abortion

===Chronic brucellosis===
*>12 months of symptoms
*Divided into 3 categories:
#relapse: relapsing symptoms after treatment.  
#chronic localized infection
#Delayed convalescence

==Differential Diagnosis==
{{Lower respiratory zoonotic infections}}

==Evaluation==
*Culture is often negative
*Serology is most useful in diagnosis.

==Management==
*Relapse is associated with use of beta-lactams, cephalosporins, macroides.  
===Adults (>8 years old)=== 
Combination therapy to decrease the incidence of relapse and duration recommended at a minimum of 6 weeks<ref>CDC Brucellosis Reference Guide https://www.cdc.gov/brucellosis/pdf/brucellosi-reference-guide.pdf</ref>
*Oral [[doxycycline]] (2–4 mg/kg per day, maximum 200 mg/day, in 2 divided doses) or oral
tetracycline (30–40 mg/kg per day, maximum 2 g/day, in 4 divided doses) '''-and-'''
*[[Rifampin]] (15–20 mg/kg per day, maximum 600–900 mg/day, in 1 or 2 divided doses).
*Combination therapy with trimethoprim-sulfamethoxazole (TMP-SMZ) can be used if
tetracyclines are contraindicated. 

===Children (<8 years old)===
*Oral [[TMP-SMZ]] (trimethoprim, 10 mg/kg per day, maximum 480 mg/day; and sulfamethoxazole,
50 mg/kg per day, maximum 2.4 g/day) divided in 2 doses for 4 to 6 weeks.
*Consider adding rifampin. 
*Tetracyclines (such as doxycycline) should be avoided in children less than 8 years of age. 

===Post-exposure prophylaxis===
*Doxycycline x 6 weeks.

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Category'''
| align="center" style="background:#f0f0f0;"|'''Antibiotic'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| [[Penicillins]]||[[Penicillin G]]||X1
|-
| ||[[Penicillin V]]||X1
|-
| Anti-Staphylocccal [[Penicillins]]||[[Methicillin]]||X1
|-
| ||[[Nafcillin]]/[[Oxacillin]]||X1
|-
| ||[[Cloxacillin]]/[[Diclox.]]||X1
|-
| Amino-[[Penicillins]]||[[AMP]]/[[Amox]]||X1
|-
| ||[[Amox-Clav]]||X1
|-
| ||[[AMP-Sulb]]||X1
|-
| Anti-Pseudomonal [[Penicillins]]||[[Ticarcillin]]||X1
|-
| ||[[Ticar-Clav]]||X1
|-
| ||[[Pip-Tazo]]||X1
|-
| ||[[Piperacillin]]||X1
|-
| [[Carbapenems]]||[[Doripenem]]||X1
|-
| ||[[Ertapenem]]||X1
|-
| ||[[Imipenem]]||X1
|-
| ||[[Meropenem]]||X1
|-
| ||[[Aztreonam]]||X1
|-
| [[Fluroquinolones]]||[[Ciprofloxacin]]||X1
|-
| ||[[Ofloxacin]]||X1
|-
| ||[[Pefloxacin]]||X1
|-
| ||[[Levofloxacin]]||X1
|-
| ||[[Moxifloxacin]]||X1
|-
| ||[[Gemifloxacin]]||X1
|-
| ||[[Gatifloxacin]]||X1
|-
| 1st G [[Cephalo]]||[[Cefazolin]]||X1
|-
| 2nd G. [[Cephalo]]||[[Cefotetan]]||X1
|-
| ||[[Cefoxitin]]||X1
|-
| ||[[Cefuroxime]]||X1
|-
| 3rd/4th G. [[Cephalo]]||[[Cefotaxime]]||X1
|-
| ||[[Cefizoxime]]||X1
|-
| ||[[CefTRIAXone]]||X1
|-
| ||[[Ceftaroline]]||X1
|-
| ||[[CefTAZidime]]||X1
|-
| ||[[Cefepime]]||X1
|-
| Oral 1st G. [[Cephalo]]||[[Cefadroxil]]||X1
|-
| ||[[Cephalexin]]||X1
|-
| Oral 2nd G. [[Cephalo]]||[[Cefaclor]]/[[Loracarbef]]||X1
|-
| ||[[Cefproxil]]||X1
|-
| ||[[Cefuroxime axetil]]||X1
|-
| Oral 3rd G. [[Cephalo]]||[[Cefixime]]||X1
|-
| ||[[Ceftibuten]]||X1
|-
| ||[[Cefpodox]]/[[Cefdinir]]/[[Cefditoren]]||X1
|-
| [[Aminoglycosides]]||[[Gentamicin]]||'''S+'''
|-
| ||[[Tobramycin]]||'''S+'''
|-
| ||[[Amikacin]]||'''S+'''
|-
| ||[[Chloramphenicol]]||'''S'''
|-
| ||[[Clindamycin]]||R
|-
| [[Macrolides]]||[[Erythromycin]]||R
|-
| ||[[Azithromycin]]||R
|-
| ||[[Clarithromycin]]||R
|-
| Ketolide||[[Telithromycin]]||R
|-
| Tetracyclines||[[Doxycycline]]||'''S'''
|-
| ||[[Minocycline]]||'''S'''
|-
| Glycylcycline||[[Tigecycline]]||X1
|-
| ||[[Daptomycin]]||R
|-
| Glyco/Lipoclycopeptides||[[Vancomycin]]||R
|-
| ||[[Teicoplanin]]||R
|-
| ||[[Telavancin]]||R
|-
| ||[[Fusidic Acid]]||X1
|-
| ||[[Trimethoprim]]||X2
|-
| ||[[TMP-SMX]]||X2
|-
| Urinary Agents||[[Nitrofurantoin]]||X1
|-
| ||[[Fosfomycin]]||X1
|-
| Other||[[Rifampin]]||'''S+'''
|-
| ||[[Metronidazole]]||R
|-
| ||[[Quinupristin dalfoppristin]]||X1
|-
| ||[[Linezolid]]||R
|-
| ||[[Colistimethate]]||X1
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==Table Overview==
{{Clinically Relevant Bacteria}}

==See Also==
*[[Microbiology (Main)]]

==References==
#http://www.cdc.gov/brucellosis/
#WHO Library Cataloguing-in-Publication Data
Brucellosis in humans and animals.
Produced by the World Health Organization in collaboration with the Food and Agriculture Organization
of the United Nations and World Organisation for Animal Health
Principal author: M.J. Corbel.
1.Brucellosis - prevention and control. 2.Brucellosis - epidemiology. 3.Brucellosis - complications.
4.Guidelines. I.Corbel, M.J. II.World Health Organization. III.Food and Agriculture Organization of the
United Nations. IV.World Organisation for Animal Health.
<references/>

[[Category:ID]]