CMV colitis: Difference between revisions
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*Severe systemic illness is found in immunosuppressed hosts | *Severe systemic illness is found in immunosuppressed hosts | ||
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*Anorexia | *Anorexia | ||
Revision as of 13:36, 13 July 2016
Background
- CMV is part of the Herpesviridae family
- 50-80% of the world's population is seropositive for CMV
- Causes a mild or undetectable infection in immunocompetent hosts
- Severe systemic illness is found in immunosuppressed hosts
Clinical Features
- Fever
- Anorexia
- Malaise
- Weight loss
- Dehydration
- Abdominal pain
- Abdominal distention
- Nausea
- Vomiting
- Chronic watery diarrhea
- Bloody diarrhea
- Constipation
- Worsening symptoms of inflammatory bowel disease
Differential Diagnosis
Colitis
- Viral gastroenteritis
- Bacterial gastroenteritis
- Campylobacter infections
- Clostridium difficile colitis
- Colon cancer
- Crohn disease
- Cryptosporidiosis
- Mycobacterium Avium-Intracellulare
- Toxic megacolon
- Ulcerative colitis
- Ischemic bowel disease (e.g. mesenteric ischemia, strangulated hernia)
- Pseudomembranous enterocolitis
- Lymphoma
- Ileocecal amebiasis
- Sarcoidosis
- Yersinia
- Campylobacter
CMV Diseases
Diagnosis
Management
Disposition
- Ganciclovir 5mg/kg IV q12hrs x 21 days (or until resolution of symptoms)
- Foscarnet 90mg/kg IV q12hrs daily x 21 days (or until resolution of symptoms)