CMV colitis: Difference between revisions
ClaireLewis (talk | contribs) No edit summary |
|||
(9 intermediate revisions by 4 users not shown) | |||
Line 1: | Line 1: | ||
==Background== | ==Background== | ||
*CMV is part of the Herpesviridae family | |||
*50-80% of the world's population is seropositive for CMV | |||
*Causes a mild or undetectable infection in immunocompetent hosts | |||
*Severe systemic illness is found in immunosuppressed hosts | |||
==Clinical | ==Clinical Features== | ||
*[[Fever]] | |||
*Anorexia | |||
*Malaise | |||
*[[Abdominal pain]], Abdominal distention, [[constipation]] | |||
*[[Nausea/vomiting]] | |||
*Chronic watery [[diarrhea]] | |||
*[[rectal bleeding|Bloody diarrhea]] | |||
*Worsening symptoms of [[inflammatory bowel disease]] | |||
*Weight loss | |||
*[[Dehydration]] | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
{{Colitis DDX}} | |||
== | {{CMV types}} | ||
==Evaluation== | |||
==Management== | ==Management== | ||
{{CMV colitis treatment}} | |||
==Disposition== | ==Disposition== | ||
==See Also== | ==See Also== | ||
*[[Cytomegalovirus (CMV) infection]] | *[[Cytomegalovirus (CMV) infection]] |
Latest revision as of 20:03, 29 September 2019
Background
- CMV is part of the Herpesviridae family
- 50-80% of the world's population is seropositive for CMV
- Causes a mild or undetectable infection in immunocompetent hosts
- Severe systemic illness is found in immunosuppressed hosts
Clinical Features
- Fever
- Anorexia
- Malaise
- Abdominal pain, Abdominal distention, constipation
- Nausea/vomiting
- Chronic watery diarrhea
- Bloody diarrhea
- Worsening symptoms of inflammatory bowel disease
- Weight loss
- Dehydration
Differential Diagnosis
Colitis
- Viral gastroenteritis
- Bacterial gastroenteritis
- Campylobacter infections
- Clostridium difficile colitis
- Colon cancer
- Crohn disease
- Cryptosporidiosis
- Mycobacterium Avium-Intracellulare
- Toxic megacolon
- Ulcerative colitis
- Ischemic bowel disease (e.g. mesenteric ischemia, strangulated hernia)
- Pseudomembranous enterocolitis
- Lymphoma
- Ileocecal amebiasis
- Sarcoidosis
- Yersinia
- Campylobacter
CMV Diseases
Evaluation
Management
- Ganciclovir 5mg/kg IV q12hrs x 21 days (or until resolution of symptoms)
- Foscarnet 90mg/kg IV q12hrs daily x 21 days (or until resolution of symptoms)