Caspofungin

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Administration

  • Type: Antifungal, particularly used for aspergillosis and candidiasis
  • Dosage Forms:
  • Routes of Administration: IV
  • Common Trade Names:

Adult Dosing

  • 50-150 mg IV daily

Pediatric Dosing

3 months or older

  • 50-70 mg/m(2) daily

Special Populations

Renal Dosing

  • Adult:
  • Pediatric:

Hepatic Dosing

  • Adult:
  • Pediatric:

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Erythema multiforme, Stevens-Johnson syndrome
  • Pancreatitis, hepatic failure
  • Sepsis
  • Nephrotoxicity
  • Pleural effusion, respiratory distress
  • Angioedema

Common

  • Hypotension
  • Rash
  • Diarrhea
  • Histaminergic reaction (flushing, warmth, pruritus)
  • Transaminitis
  • Fever

Pharmacology

  • Half-life: 13-15 hours
  • Metabolism: spontaneous degradation, hydrolysis and N-acetylation
  • Excretion: Fecal, renal

Mechanism of Action

*Inhibits beta (1,3)-D-glucan synthesis in fungal cell wall

Comments

See Also

References