Difference between revisions of "Cefepime"

(General)
(Adult Dosing)
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==Adult Dosing==
 
==Adult Dosing==
 +
'''<big>Bacterial Infections</big>'''
 +
* 1-2 g IV q12H (Max: 6 g/24h; dose, duration varies with infection type, severity)
 +
 +
'''<big>Febrile Neutropenia</big>'''
 +
* 2g IV q8H
 +
 +
<big>'''UTI, mild-moderate'''</big>
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* 0.5-1g IV/IM q12H x7-10 days (IM only for UTI due to E. coli)
 +
 +
<big>'''UTI, severe'''</big>
 +
* 2g IV q12H x10 days
 +
 +
<big>'''Renal dosing'''</big>
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* Febrile Neutropenia: CrCl 30-60: 2 g q12H; CrCl 11-29: 2 g q24H; CrCL <11: 2gx1, then 1g q24H; HD: 1g q24H, give after dialysis; PD: 2g q48H
 +
*All other infections: CrCl 30-60: give q24h; CrCl 11-29: give usual dose x1, then 0.5-1 g q24h; CrCl <11: give usual dose x1, then 250-500 mg q24h; HD: 1 g x1, then 500 mg q24h, give after dialysis; PD: give usual dose q48h
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 +
<big>'''Hepatic Doseing'''</big>
 +
* no adjustment
  
 
==Pediatric Dosing==
 
==Pediatric Dosing==

Revision as of 00:06, 17 May 2014

General

  • Type: Fourth generation cephalosporin
  • Dosage Forms: IV, IM
  • Common Trade Names: Maxipime

Adult Dosing

Bacterial Infections

  • 1-2 g IV q12H (Max: 6 g/24h; dose, duration varies with infection type, severity)

Febrile Neutropenia

  • 2g IV q8H

UTI, mild-moderate

  • 0.5-1g IV/IM q12H x7-10 days (IM only for UTI due to E. coli)

UTI, severe

  • 2g IV q12H x10 days

Renal dosing

  • Febrile Neutropenia: CrCl 30-60: 2 g q12H; CrCl 11-29: 2 g q24H; CrCL <11: 2gx1, then 1g q24H; HD: 1g q24H, give after dialysis; PD: 2g q48H
  • All other infections: CrCl 30-60: give q24h; CrCl 11-29: give usual dose x1, then 0.5-1 g q24h; CrCl <11: give usual dose x1, then 250-500 mg q24h; HD: 1 g x1, then 500 mg q24h, give after dialysis; PD: give usual dose q48h

Hepatic Doseing

  • no adjustment

Pediatric Dosing

Special Populations

  • Pregnancy:
  • Lactation:
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action:

See Also

Source