Cefepime
General
- Type: Fourth generation cephalosporin
- Dosage Forms: IV, IM
- Common Trade Names: Maxipime
Adult Dosing
Bacterial Infections
- 1-2 g IV q12H (Max: 6 g/24h; dose, duration varies with infection type, severity)
Febrile Neutropenia
- 2g IV q8H
UTI, mild-moderate
- 0.5-1g IV/IM q12H x7-10 days (IM only for UTI due to E. coli)
UTI, severe
- 2g IV q12H x10 days
Renal dosing
- Febrile Neutropenia: CrCl 30-60: 2 g q12H; CrCl 11-29: 2 g q24H; CrCL <11: 2gx1, then 1g q24H; HD: 1g q24H, give after dialysis; PD: 2g q48H
- All other infections: CrCl 30-60: give q24h; CrCl 11-29: give usual dose x1, then 0.5-1 g q24h; CrCl <11: give usual dose x1, then 250-500 mg q24h; HD: 1 g x1, then 500 mg q24h, give after dialysis; PD: give usual dose q48h
Hepatic Doseing
- no adjustment
Pediatric Dosing
Special Populations
- Pregnancy:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
See Also
Source
- Epocrates