Cefprozil

Administration

• Type: 2nd generation cephalosporin
• Dosage Forms: tablet, oral suspension
• Dosage Strengths: tablet: 250mg, 500mg; oral suspension: 125mg/5mL, 250mg/5mL
• Routes of Administration: PO
• Common Trade Names: Cefzil

Adult Dosing

Infections, bacterial:

• 250-500mg PO q12h x 10 days

Pediatric Dosing

infections, bacterial:

• 30mg/kg/day PO divided q12h x 10 days, max 1000mg/day

Special Populations

• Pregnancy Rating: B
• Lactation risk: probably safe

Renal Dosing

• Adult: CrCl < 30: decrease dose 50%
• Pediatric:CrCl < 30: decrease dose 50%

Hepatic Dosing

• Adult: none defined
• Pediatric: none defined

Contraindications

• Allergy to class/drug
• PKU

Adverse Reactions

Serious

• anaphylaxis
• seizures
• nephrotoxicity
• leukopenia or thrombocytopenia
• steven-johnson syndrome
• c-diff associated diarrhea

Common

• nausea
• diarrhea
• vomiting
• transaminitis
• dizziness
• rash
• eosinophilia

Pharmacology

• Half-life: 1.3 h
• Metabolism: hepatic
• Excretion: unchanged in urine (61%)

Mechanism of Action

bactericidal, inhibits cell wall mucopeptide synthesis