Difference between revisions of "Ceftriaxone"

(Created page with "==General== *Type: *Dosage Forms: *Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Contraindications== *Allergy to class/drug ==Adverse Reactions== ==Pharma...")
 
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==General==
 
==General==
*Type:  
+
*Type: 3rd generation [[cephalosporins]]
*Dosage Forms:
+
*Dosage Forms: IM, IV
*Common Trade Names:  
+
*Common Trade Names: Rocephin
  
 
==Adult Dosing==
 
==Adult Dosing==
 +
*1-2g IM/IV q24h
 +
**Max: 4g/24h
 +
 +
===Bacterial [[Meningitis]]===
 +
*4g IV divided q12-24h x 7-21 days
 +
 +
===[[Gonococcal]]===
 +
*Uncomplicated, initial: 250mg IM x 1
 +
**Also treat for chlamydia regardless of test results
 +
*Uncomplicated, recurrent of persistent: 500-1000mg IM x 1
 +
*Disseminated: 1g IM/IV q24h
 +
**May switch to cefixime PO after 24-48h if clinical improvement
 +
*Conjunctivitis: 1g IM x 1
 +
*Prophylaxis (sexual assault victims)
 +
**250mg IM x 1
 +
 +
===[[PID]]===
 +
*250mg IM x 1
 +
*Use with doxycycline +/- metronidazole
 +
 +
===[[Sinusitis]], Severe===
 +
*1-2g IV q12-24h x 7-10 days
 +
 +
===[[Endocarditis]]===
 +
*1g IM/IV x 1
 +
**30-60 min before procedure
 +
 +
===[[Proctitis]]===
 +
*250mg IM x 1
 +
**Give with doxycycline
 +
 +
===[[Epididymitis]]===
 +
*250mg IM x 1
 +
**Give with doxycycline
 +
 +
===Surgical Prophylaxis===
 +
*1g IV x 1
 +
**Give 0.5-2h preop
 +
 +
===Chancroid===
 +
*250mg IM x 1
 +
**Give with doxycycline
 +
 +
===[[Typhoid Fever]]===
 +
*60mg/kg IV q24h x 2wk
 +
**Max: 4g/24h
  
 
==Pediatric Dosing==
 
==Pediatric Dosing==
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==Pharmacology==
 
==Pharmacology==
*Half-life:  
+
*Half-life: 5.8-8.7h, 15h (CrCl 5-15)
*Metabolism:  
+
*Metabolism: CYP450
*Excretion:  
+
*Excretion: Primarily urine
*Mechanism of Action:
+
*Mechanism of Action: bactericidal; inhibits cell wall synthesis
  
 
==Pregnancy/Lactation==
 
==Pregnancy/Lactation==
*Pregnancy:
+
*Pregnancy: B
*Lactation:
+
*Lactation: Probably safe
 
 
==Overdose Management==
 
  
 
==See Also==
 
==See Also==
 +
*[[Antibiotics (Main)]]
  
 
==Source==
 
==Source==
  
 
[[Category:Drugs]]
 
[[Category:Drugs]]

Revision as of 07:01, 7 February 2014

General

  • Type: 3rd generation cephalosporins
  • Dosage Forms: IM, IV
  • Common Trade Names: Rocephin

Adult Dosing

  • 1-2g IM/IV q24h
    • Max: 4g/24h

Bacterial Meningitis

  • 4g IV divided q12-24h x 7-21 days

Gonococcal

  • Uncomplicated, initial: 250mg IM x 1
    • Also treat for chlamydia regardless of test results
  • Uncomplicated, recurrent of persistent: 500-1000mg IM x 1
  • Disseminated: 1g IM/IV q24h
    • May switch to cefixime PO after 24-48h if clinical improvement
  • Conjunctivitis: 1g IM x 1
  • Prophylaxis (sexual assault victims)
    • 250mg IM x 1

PID

  • 250mg IM x 1
  • Use with doxycycline +/- metronidazole

Sinusitis, Severe

  • 1-2g IV q12-24h x 7-10 days

Endocarditis

  • 1g IM/IV x 1
    • 30-60 min before procedure

Proctitis

  • 250mg IM x 1
    • Give with doxycycline

Epididymitis

  • 250mg IM x 1
    • Give with doxycycline

Surgical Prophylaxis

  • 1g IV x 1
    • Give 0.5-2h preop

Chancroid

  • 250mg IM x 1
    • Give with doxycycline

Typhoid Fever

  • 60mg/kg IV q24h x 2wk
    • Max: 4g/24h

Pediatric Dosing

Contraindications

  • Allergy to class/drug

Adverse Reactions

Pharmacology

  • Half-life: 5.8-8.7h, 15h (CrCl 5-15)
  • Metabolism: CYP450
  • Excretion: Primarily urine
  • Mechanism of Action: bactericidal; inhibits cell wall synthesis

Pregnancy/Lactation

  • Pregnancy: B
  • Lactation: Probably safe

See Also

Source