Difference between revisions of "Ceftriaxone"
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==General== | ==General== | ||
| − | *Type: | + | *Type: 3rd generation [[cephalosporins]] |
| − | *Dosage Forms: | + | *Dosage Forms: IM, IV |
| − | *Common Trade Names: | + | *Common Trade Names: Rocephin |
==Adult Dosing== | ==Adult Dosing== | ||
| + | *1-2g IM/IV q24h | ||
| + | **Max: 4g/24h | ||
| + | |||
| + | ===Bacterial [[Meningitis]]=== | ||
| + | *4g IV divided q12-24h x 7-21 days | ||
| + | |||
| + | ===[[Gonococcal]]=== | ||
| + | *Uncomplicated, initial: 250mg IM x 1 | ||
| + | **Also treat for chlamydia regardless of test results | ||
| + | *Uncomplicated, recurrent of persistent: 500-1000mg IM x 1 | ||
| + | *Disseminated: 1g IM/IV q24h | ||
| + | **May switch to cefixime PO after 24-48h if clinical improvement | ||
| + | *Conjunctivitis: 1g IM x 1 | ||
| + | *Prophylaxis (sexual assault victims) | ||
| + | **250mg IM x 1 | ||
| + | |||
| + | ===[[PID]]=== | ||
| + | *250mg IM x 1 | ||
| + | *Use with doxycycline +/- metronidazole | ||
| + | |||
| + | ===[[Sinusitis]], Severe=== | ||
| + | *1-2g IV q12-24h x 7-10 days | ||
| + | |||
| + | ===[[Endocarditis]]=== | ||
| + | *1g IM/IV x 1 | ||
| + | **30-60 min before procedure | ||
| + | |||
| + | ===[[Proctitis]]=== | ||
| + | *250mg IM x 1 | ||
| + | **Give with doxycycline | ||
| + | |||
| + | ===[[Epididymitis]]=== | ||
| + | *250mg IM x 1 | ||
| + | **Give with doxycycline | ||
| + | |||
| + | ===Surgical Prophylaxis=== | ||
| + | *1g IV x 1 | ||
| + | **Give 0.5-2h preop | ||
| + | |||
| + | ===Chancroid=== | ||
| + | *250mg IM x 1 | ||
| + | **Give with doxycycline | ||
| + | |||
| + | ===[[Typhoid Fever]]=== | ||
| + | *60mg/kg IV q24h x 2wk | ||
| + | **Max: 4g/24h | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
| Line 14: | Line 60: | ||
==Pharmacology== | ==Pharmacology== | ||
| − | *Half-life: | + | *Half-life: 5.8-8.7h, 15h (CrCl 5-15) |
| − | *Metabolism: | + | *Metabolism: CYP450 |
| − | *Excretion: | + | *Excretion: Primarily urine |
| − | *Mechanism of Action: | + | *Mechanism of Action: bactericidal; inhibits cell wall synthesis |
==Pregnancy/Lactation== | ==Pregnancy/Lactation== | ||
| − | *Pregnancy: | + | *Pregnancy: B |
| − | *Lactation: | + | *Lactation: Probably safe |
| − | |||
| − | |||
==See Also== | ==See Also== | ||
| + | *[[Antibiotics (Main)]] | ||
==Source== | ==Source== | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
Revision as of 07:01, 7 February 2014
Contents
General
- Type: 3rd generation cephalosporins
- Dosage Forms: IM, IV
- Common Trade Names: Rocephin
Adult Dosing
- 1-2g IM/IV q24h
- Max: 4g/24h
Bacterial Meningitis
- 4g IV divided q12-24h x 7-21 days
Gonococcal
- Uncomplicated, initial: 250mg IM x 1
- Also treat for chlamydia regardless of test results
- Uncomplicated, recurrent of persistent: 500-1000mg IM x 1
- Disseminated: 1g IM/IV q24h
- May switch to cefixime PO after 24-48h if clinical improvement
- Conjunctivitis: 1g IM x 1
- Prophylaxis (sexual assault victims)
- 250mg IM x 1
PID
- 250mg IM x 1
- Use with doxycycline +/- metronidazole
Sinusitis, Severe
- 1-2g IV q12-24h x 7-10 days
Endocarditis
- 1g IM/IV x 1
- 30-60 min before procedure
Proctitis
- 250mg IM x 1
- Give with doxycycline
Epididymitis
- 250mg IM x 1
- Give with doxycycline
Surgical Prophylaxis
- 1g IV x 1
- Give 0.5-2h preop
Chancroid
- 250mg IM x 1
- Give with doxycycline
Typhoid Fever
- 60mg/kg IV q24h x 2wk
- Max: 4g/24h
Pediatric Dosing
Contraindications
- Allergy to class/drug
Adverse Reactions
Pharmacology
- Half-life: 5.8-8.7h, 15h (CrCl 5-15)
- Metabolism: CYP450
- Excretion: Primarily urine
- Mechanism of Action: bactericidal; inhibits cell wall synthesis
Pregnancy/Lactation
- Pregnancy: B
- Lactation: Probably safe