Difference between revisions of "Ceftriaxone"

(Adult Dosing)
(Pediatric Dosing)
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==Pediatric Dosing==
 
==Pediatric Dosing==
 +
===General (<7 Days Old)===
 +
*50 mg/kg IM/IV q24h
 +
*First ED Dose: 50 mg/kg IM/IV x 1
 +
 +
===General (7 Days - 1 Month)===
 +
*<2000g
 +
**50 mg/kg IM/IV q24h
 +
**First ED Dose: 50 mg/kg IM/IV x 1
 +
*>2000g
 +
**50-75 mg/kg IM/IV q24h
 +
**First ED Dose: 50-75 mg/kg IM/IV x 1
 +
 +
===General (>1 Month - Adult)===
 +
*50-100 mg/kg IM/IV divided q12-24h
 +
*First ED Dose: 50-100 mg/kg IM/IV x 1
 +
*Max: 4g/24h
  
 
==Contraindications==
 
==Contraindications==

Revision as of 20:53, 27 February 2014

General

  • Type: 3rd generation cephalosporins
  • Dosage Forms: IM, IV
  • Common Trade Names: Rocephin

Adult Dosing

General

  • 1-2g IM/IV q24h
  • First ED Dose: 1g IM/IV x 1
  • Max: 4g/24h

Bacterial Meningitis

  • 4g IV divided q12-24h x 7-21 days
  • First ED Dose: 2g IM/IV x 1

Gonococcal

  • Uncomplicated, initial: 250mg IM x 1
    • Also treat for chlamydia regardless of test results
  • Uncomplicated, recurrent of persistent: 500-1000mg IM x 1
  • Disseminated: 1g IM/IV q24h
    • May switch to cefixime PO after 24-48h if clinical improvement
  • Conjunctivitis: 1g IM x 1
  • Prophylaxis (sexual assault victims)
    • 250mg IM x 1

PID

  • 250mg IM x 1
  • Use with doxycycline +/- metronidazole

Sinusitis, Severe

  • 1-2g IV q12-24h x 7-10 days

Endocarditis

  • 1g IM/IV x 1
    • 30-60 min before procedure

Proctitis, Epididymitis, Chancroid

  • 250mg IM x 1
    • Give with doxycycline

Surgical Prophylaxis

  • 1g IV x 1
    • Give 0.5-2h preop

Typhoid Fever

  • 60mg/kg IV q24h x 2wk
  • Max: 4g/24h

Pediatric Dosing

General (<7 Days Old)

  • 50 mg/kg IM/IV q24h
  • First ED Dose: 50 mg/kg IM/IV x 1

General (7 Days - 1 Month)

  • <2000g
    • 50 mg/kg IM/IV q24h
    • First ED Dose: 50 mg/kg IM/IV x 1
  • >2000g
    • 50-75 mg/kg IM/IV q24h
    • First ED Dose: 50-75 mg/kg IM/IV x 1

General (>1 Month - Adult)

  • 50-100 mg/kg IM/IV divided q12-24h
  • First ED Dose: 50-100 mg/kg IM/IV x 1
  • Max: 4g/24h

Contraindications

  • Allergy to class/drug

Adverse Reactions

Pharmacology

  • Half-life: 5.8-8.7h, 15h (CrCl 5-15)
  • Metabolism: CYP450
  • Excretion: Primarily urine
  • Mechanism of Action: bactericidal; inhibits cell wall synthesis

Pregnancy/Lactation

  • Pregnancy: B
  • Lactation: Probably safe

See Also

Source