Ceftriaxone

Revision as of 07:01, 7 February 2014 by Rossdonaldson1 (talk | contribs)

General

  • Type: 3rd generation cephalosporins
  • Dosage Forms: IM, IV
  • Common Trade Names: Rocephin

Adult Dosing

  • 1-2g IM/IV q24h
    • Max: 4g/24h

Bacterial Meningitis

  • 4g IV divided q12-24h x 7-21 days

Gonococcal

  • Uncomplicated, initial: 250mg IM x 1
    • Also treat for chlamydia regardless of test results
  • Uncomplicated, recurrent of persistent: 500-1000mg IM x 1
  • Disseminated: 1g IM/IV q24h
    • May switch to cefixime PO after 24-48h if clinical improvement
  • Conjunctivitis: 1g IM x 1
  • Prophylaxis (sexual assault victims)
    • 250mg IM x 1

PID

  • 250mg IM x 1
  • Use with doxycycline +/- metronidazole

Sinusitis, Severe

  • 1-2g IV q12-24h x 7-10 days

Endocarditis

  • 1g IM/IV x 1
    • 30-60 min before procedure

Proctitis

  • 250mg IM x 1
    • Give with doxycycline

Epididymitis

  • 250mg IM x 1
    • Give with doxycycline

Surgical Prophylaxis

  • 1g IV x 1
    • Give 0.5-2h preop

Chancroid

  • 250mg IM x 1
    • Give with doxycycline

Typhoid Fever

  • 60mg/kg IV q24h x 2wk
    • Max: 4g/24h

Pediatric Dosing

Contraindications

  • Allergy to class/drug

Adverse Reactions

Pharmacology

  • Half-life: 5.8-8.7h, 15h (CrCl 5-15)
  • Metabolism: CYP450
  • Excretion: Primarily urine
  • Mechanism of Action: bactericidal; inhibits cell wall synthesis

Pregnancy/Lactation

  • Pregnancy: B
  • Lactation: Probably safe

See Also

Source