Difference between revisions of "Celecoxib"

(Text replacement - "qd" to "QD")
(edited dosage forms, strengths, routes of administration, trade names)
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*Type: [[Nonsteroidal anti-inflammatory drugs]] (NSAID), COX-2 Selective
*Type: [[Nonsteroidal anti-inflammatory drugs]] (NSAID), COX-2 Selective
*Dosage Forms: 50,100,200,400
*Dosage Forms: capsule
*Routes of Administration: Oral
*Dosage Strengths: 50, 100, 200, 400mg
*Common Trade Names: CeleBREX
*Routes of Administration: PO
*Common Trade Names: Celebrex
==Adult Dosing==
==Adult Dosing==

Revision as of 18:31, 13 October 2017


  • Type: Nonsteroidal anti-inflammatory drugs (NSAID), COX-2 Selective
  • Dosage Forms: capsule
  • Dosage Strengths: 50, 100, 200, 400mg
  • Routes of Administration: PO
  • Common Trade Names: Celebrex

Adult Dosing

  • Rheumatoid arthritis: 100-200mg PO bid
    • Use lowest effective dose, shortest effective treatment duration
    • Consider starting at 50% of lowest dose if poor CYP2C9 metabolizer
  • Dysmenorrhea: 200mg PO bid
    • Start: 400mg PO x1, may give additional 200mg on day 1 if needed
  • Pain, acute: 200mg PO bid
    • Start: 400mg PO x1, may give additional 200mg on day 1 if needed

Pediatric Dosing

Only for ages > 2 years old

Special Populations

Renal Dosing

  • Avoid use in severe renal impairment

Hepatic Dosing

  • Adult:Child-Pugh Class B: decrease dose 50%; Child-Pugh Class C: avoid use


  • hypersens. to drug/class/compon.
  • hypersens. to sulfonamides
  • ASA or NSAID-induced asthma or urticaria
  • aspirin triad
  • pregnancy starting at 30 wk gestation
  • CABG surgery periop use
  • GI bleeding

Adverse Reactions




  • Half-life: 11hr
  • Metabolism: CYP450
  • Excretion: feces, urine

Mechanism of Action


See Also


<Epocrates, UpToDate>