Celecoxib: Difference between revisions
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==Administration== | ==Administration== | ||
*Type: Nonsteroidal | *Type: [[Nonsteroidal anti-inflammatory drugs]] (NSAID), COX-2 Selective | ||
*Dosage Forms: 50,100,200,400 | *Dosage Forms: 50,100,200,400 | ||
*Routes of Administration: Oral | *Routes of Administration: Oral |
Revision as of 05:56, 12 July 2016
Administration
- Type: Nonsteroidal anti-inflammatory drugs (NSAID), COX-2 Selective
- Dosage Forms: 50,100,200,400
- Routes of Administration: Oral
- Common Trade Names: CeleBREX
Adult Dosing
- Osteoarthritis: 200 mg PO qd
- Rheumatoid arthritis: 100-200 mg PO bid
- Use lowest effective dose, shortest effective tx duration
- Consider starting at 50% of lowest dose if poor CYP2C9 metabolizer
- Ankylosing spondylitis: 200 mg PO qd
- Max: 400 mg/day
- Dysmenorrhea: 200 mg PO bid
- Start: 400 mg PO x1, may give additional 200 mg on day 1 if needed
- Pain, acute: 200 mg PO bid
- Start: 400 mg PO x1, may give additional 200 mg on day 1 if needed
Pediatric Dosing
Only for ages > 2 years old
- Juvenile idiopathic arthritis
- 10-25 kg]: 50 mg PO bid
**>25 kg: 100 mg PO bid
Special Populations
- Pregnancy Risk Factor: C (prior to 30 weeks gestation)/D (≥30 weeks gestation)
Renal Dosing
- Avoid use in severe renal impairment
Hepatic Dosing
- Adult:Child-Pugh Class B: decr. dose 50%; Child-Pugh Class C: avoid use
Contraindications
- hypersens. to drug/class/compon.
- hypersens. to sulfonamides
- ASA or NSAID-induced asthma or urticaria
- aspirin triad
- pregnancy starting at 30 wk gestation
- CABG surgery periop use
- GI bleeding
Adverse Reactions
Serious
- GI bleeding
- GI perforation/ulcer
- MI
- stroke
- thromboembolism
Common
- headache
- dyspepsia
- URI
- diarrhea
- abdominal pain
- nausea/vomiting
Pharmacology
- Half-life: 11hr
- Metabolism: CYP450
- Excretion: feces, urine
Mechanism of Action
Comments
See Also
References
<Epocrates, UpToDate>