Difference between revisions of "Celecoxib"

(Special Populations)
(Contraindications)
Line 41: Line 41:
 
*hypersens. to drug/class/compon.
 
*hypersens. to drug/class/compon.
 
*hypersens. to sulfonamides
 
*hypersens. to sulfonamides
*ASA or NSAID-induced asthma or urticaria
+
*[[ASA]] or [[NSAID]]-induced [[asthma]] or [[urticaria]]
 
*aspirin triad
 
*aspirin triad
 
*pregnancy starting at 30 wk gestation
 
*pregnancy starting at 30 wk gestation
 
*CABG surgery periop use
 
*CABG surgery periop use
*GI bleeding
+
*[[GI bleeding]]
  
 
==Adverse Reactions==
 
==Adverse Reactions==

Revision as of 06:00, 12 July 2016

Administration

Adult Dosing

  • Rheumatoid arthritis: 100-200 mg PO bid
    • Use lowest effective dose, shortest effective tx duration
    • Consider starting at 50% of lowest dose if poor CYP2C9 metabolizer
  • Dysmenorrhea: 200 mg PO bid
    • Start: 400 mg PO x1, may give additional 200 mg on day 1 if needed
  • Pain, acute: 200 mg PO bid
    • Start: 400 mg PO x1, may give additional 200 mg on day 1 if needed

Pediatric Dosing

Only for ages > 2 years old

Special Populations

Renal Dosing

  • Avoid use in severe renal impairment

Hepatic Dosing

  • Adult:Child-Pugh Class B: decr. dose 50%; Child-Pugh Class C: avoid use

Contraindications

  • hypersens. to drug/class/compon.
  • hypersens. to sulfonamides
  • ASA or NSAID-induced asthma or urticaria
  • aspirin triad
  • pregnancy starting at 30 wk gestation
  • CABG surgery periop use
  • GI bleeding

Adverse Reactions

Serious

  • GI bleeding
  • GI perforation/ulcer
  • MI
  • stroke
  • thromboembolism

Common

  • headache
  • dyspepsia
  • URI
  • diarrhea
  • abdominal pain
  • nausea/vomiting

Pharmacology

  • Half-life: 11hr
  • Metabolism: CYP450
  • Excretion: feces, urine

Mechanism of Action

Comments

See Also

References

<Epocrates, UpToDate>