Difference between revisions of "Celecoxib"

(Hepatic Dosing)
(Text replacement - "0 mg" to "0mg")
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==Adult Dosing==
 
==Adult Dosing==
*[[Osteoarthritis]]: 200 mg PO qd
+
*[[Osteoarthritis]]: 200mg PO qd
  
*[[Rheumatoid arthritis]]: 100-200 mg PO bid
+
*[[Rheumatoid arthritis]]: 100-200mg PO bid
 
**Use lowest effective dose, shortest effective treatment duration
 
**Use lowest effective dose, shortest effective treatment duration
 
**Consider starting at 50% of lowest dose if poor CYP2C9 metabolizer
 
**Consider starting at 50% of lowest dose if poor CYP2C9 metabolizer
  
*[[Ankylosing spondylitis]]: 200 mg PO qd
+
*[[Ankylosing spondylitis]]: 200mg PO qd
**Max: 400 mg/day
+
**Max: 400mg/day
  
*[[Dysmenorrhea]]: 200 mg PO bid
+
*[[Dysmenorrhea]]: 200mg PO bid
**Start: 400 mg PO x1, may give additional 200 mg on day 1 if needed
+
**Start: 400mg PO x1, may give additional 200mg on day 1 if needed
  
*Pain, acute: 200 mg PO bid
+
*Pain, acute: 200mg PO bid
**Start: 400 mg PO x1, may give additional 200 mg on day 1 if needed
+
**Start: 400mg PO x1, may give additional 200mg on day 1 if needed
  
 
==Pediatric Dosing==
 
==Pediatric Dosing==
 
===Only for ages > 2 years old===
 
===Only for ages > 2 years old===
 
*[[Juvenile idiopathic arthritis ]]
 
*[[Juvenile idiopathic arthritis ]]
**10-25 kg]: 50 mg PO bid
+
**10-25 kg]: 50mg PO bid
**>25 kg: 100 mg PO bid
+
**>25 kg: 100mg PO bid
  
 
==Special Populations==
 
==Special Populations==

Revision as of 01:25, 19 July 2016

Administration

Adult Dosing

  • Rheumatoid arthritis: 100-200mg PO bid
    • Use lowest effective dose, shortest effective treatment duration
    • Consider starting at 50% of lowest dose if poor CYP2C9 metabolizer
  • Dysmenorrhea: 200mg PO bid
    • Start: 400mg PO x1, may give additional 200mg on day 1 if needed
  • Pain, acute: 200mg PO bid
    • Start: 400mg PO x1, may give additional 200mg on day 1 if needed

Pediatric Dosing

Only for ages > 2 years old

Special Populations

Renal Dosing

  • Avoid use in severe renal impairment

Hepatic Dosing

  • Adult:Child-Pugh Class B: decrease dose 50%; Child-Pugh Class C: avoid use

Contraindications

  • hypersens. to drug/class/compon.
  • hypersens. to sulfonamides
  • ASA or NSAID-induced asthma or urticaria
  • aspirin triad
  • pregnancy starting at 30 wk gestation
  • CABG surgery periop use
  • GI bleeding

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 11hr
  • Metabolism: CYP450
  • Excretion: feces, urine

Mechanism of Action

Comments

See Also

References

<Epocrates, UpToDate>