Cerebral edema in DKA

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Background

  • Almost all affected pts are <20yr [1]
  • Associated with initial bicarb level; not rate of glucose drop

Clinical Features

Differential Diagnosis

Workup

Management

  • Treatment should be performed in conjunction with primary team recommendations[2]
  • Mannitol IV 1-2gm/kg OR
  • 3% NS 5-10mL/kg over 30min
  • Noncardiogenic pulmonary edema

Disposition

Admit

See Also

Sources

  1. Glaser NS, Wootton-Gorges SL, Buonocore MH, Marcin JP, Rewers A, Strain J, et al. Frequency of sub-clinical cerebral edema in children with diabetic ketoacidosis. Pediatr Diabetes. Apr 2006;7(2):75-80.
  2. Dunger DB, Sperling MA, Acerini CL, et al. (February 2004). "European Society for Paediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society consensus statement on diabetic ketoacidosis in children and adolescents". Pediatrics 113 (2): e133–40. doi:10.1542/peds.113.2.e133. PMID 14754983.