Chlorpromazine: Difference between revisions

(Created page with "==Uses== *Nausea/vomiting *intractable hiccups *psychosis ==Administration== *Dosage Forms: 25 mg/mL IV solution; 25 mg/5 mL oral solution; 10, 25, and 100 mg tablets *Routes...")
 
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==Uses==
*Nausea/vomiting
*intractable hiccups
*psychosis
==Administration==
==Administration==
*Dosage Forms: 25 mg/mL IV solution; 25 mg/5 mL oral solution; 10, 25, and 100 mg tablets
*Dosage Forms: 25 mg/mL IV solution; 25 mg/5 mL oral solution; 10, 25, and 100 mg tablets
Line 25: Line 20:
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: drug is excreted in breast milk; patients should discuss with physician risks/benefits if breastfeeding
*[[Lactation risk categories|Lactation risk]]: drug is excreted in breast milk; patients should discuss with physician risks/benefits if breastfeeding
==Indications==
*[[Nausea/vomiting]]
*intractable [[hiccups]]
*[[psychosis]]


==Contraindications==
==Contraindications==
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==References==
==References==
*1. Chlorpromazine. Retrieved from http://www.drugs.com/cdi/chlorpromazine.html
#Chlorpromazine. Retrieved from http://www.drugs.com/cdi/chlorpromazine.html
*2. US National Library of Medicine. Chlorpromazine: MedlinePlus Drug Information. Retrieved from https://www.nlm.nih.gov/medlineplus/druginfo/meds/a682040.html.
#US National Library of Medicine. Chlorpromazine: MedlinePlus Drug Information. Retrieved from https://www.nlm.nih.gov/medlineplus/druginfo/meds/a682040.html.
*3. P Young. The ICU Drug Manual. ''Chlorpromazine''. Retrieved from http://lifeinthefastlane.com/book/critical-care-drugs/chlorpromazine/
#P Young. The ICU Drug Manual. ''Chlorpromazine''. Retrieved from http://lifeinthefastlane.com/book/critical-care-drugs/chlorpromazine/
 
[[Category:Drugs]]
[[Category:Drugs]]

Revision as of 14:32, 21 January 2016

Administration

  • Dosage Forms: 25 mg/mL IV solution; 25 mg/5 mL oral solution; 10, 25, and 100 mg tablets
  • Routes of Administration: PO, IM, IV
  • Common Trade Names: Thorazine

Adult Dosing

  • Nausea/vomiting: Oral: 10 to 25 mg every 4 to 6 hours as needed. May increase, if necessary. IM: 25 mg one time. If no hypotension occurs, give 25 to 50 mg every 3 to 4 hours as needed, then switch to oral dosage. IV: 2 mg at 2 minute intervals. Do not exceed 25 mg. Dilute to 1 mg/mL.
  • Hiccups: Oral: 25 to 50 mg 3 to 4 times a day. IM: If symptoms persist for 2 to 3 days, give 25 to 50 mg IM. IV infusion: Should symptoms persist, use slow IV infusion: 25 to 50 mg in 500 to 1000 mL of saline.
  • Psychosis: IM: Initial Dose 25 to 50 mg. The dose may be repeated in one hour. Subsequent doses may be increased and given every 2 to 4 hours as needed. Oral: Initial Dose: 10 to 25 mg orally 3 times a day. Total daily doses should be increased in 20 to 50 mg increments every 3 or 4 days until symptoms are controlled.

Usual Maintenance Dose: 200 mg/day orally

Pediatric Dosing

  • should not be used in children under 6 months
  • Nausea/vomting: Nausea and vomiting: Oral: 0.5 to 1 mg/kg/dose every 4 to 6 hours as needed. IM or IV: 0.5 to 1 mg/kg/dose every 6 to 8 hours

Maximum recommended doses: less than 5 years (less than 22.7 kg): 40 mg/day 5 and older (22.7-45.5 kg): 75 mg/day

Special Populations

Indications

Contraindications

  • Allergy to class/drug

Adverse Reactions

  • Extrapyramidal reactions (e.g., Parkinson-like symptoms, dystonia, akathisia, tardive dyskinesia), drowsiness, dizziness, skin reactions or rash, dry mouth, orthostatic hypotension, amenorrhea, galactorrhea, weight gain.

References

  1. Chlorpromazine. Retrieved from http://www.drugs.com/cdi/chlorpromazine.html
  2. US National Library of Medicine. Chlorpromazine: MedlinePlus Drug Information. Retrieved from https://www.nlm.nih.gov/medlineplus/druginfo/meds/a682040.html.
  3. P Young. The ICU Drug Manual. Chlorpromazine. Retrieved from http://lifeinthefastlane.com/book/critical-care-drugs/chlorpromazine/