Chlorpromazine: Difference between revisions
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*Oral: 10 to 25 mg every 4 to 6 hours as needed. May increase, if necessary. | *Oral: 10 to 25 mg every 4 to 6 hours as needed. May increase, if necessary. | ||
*IM: 25 mg one time. If no hypotension occurs, give 25 to 50 mg every 3 to 4 hours as needed, then switch to oral dosage. | *IM: 25 mg one time. If no hypotension occurs, give 25 to 50 mg every 3 to 4 hours as needed, then switch to oral dosage. | ||
*IV: 2 mg at 2 minute intervals. Do not exceed 25 mg. Dilute to | *IV: 2 mg at 2 minute intervals. Do not exceed 25 mg. Dilute to 1mg/mL. | ||
===[[Hiccups]]=== | ===[[Hiccups]]=== | ||
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===[[Nausea/vomiting]]=== | ===[[Nausea/vomiting]]=== | ||
*Oral: 0.5 to | *Oral: 0.5 to 1mg/kg/dose every 4 to 6 hours as needed. | ||
*IM or IV: 0.5 to | *IM or IV: 0.5 to 1mg/kg/dose every 6 to 8 hours | ||
===Maximum recommended doses=== | ===Maximum recommended doses=== | ||
Revision as of 00:37, 19 July 2016
Administration
- Dosage Forms: 25 mg/mL IV solution; 25 mg/5 mL oral solution; 10, 25, and 100 mg tablets
- Routes of Administration: PO, IM, IV
- Common Trade Names: Thorazine
Adult Dosing
Nausea/vomiting
- Oral: 10 to 25 mg every 4 to 6 hours as needed. May increase, if necessary.
- IM: 25 mg one time. If no hypotension occurs, give 25 to 50 mg every 3 to 4 hours as needed, then switch to oral dosage.
- IV: 2 mg at 2 minute intervals. Do not exceed 25 mg. Dilute to 1mg/mL.
Hiccups
- Oral: 25 to 50 mg 3 to 4 times a day
- IM: If symptoms persist for 2 to 3 days, give 25 to 50 mg IM
- IV infusion: Should symptoms persist, use slow IV infusion: 25 to 50 mg in 500 to 1000 mL of saline.
Psychosis
- IM: Initial Dose 25 to 50 mg. The dose may be repeated in one hour. Subsequent doses may be increased and given every 2 to 4 hours as needed.
- Oral: Initial Dose: 10 to 25 mg orally 3 times a day. Total daily doses should be increased in 20 to 50 mg increments every 3 or 4 days until symptoms are controlled.
- Usual Maintenance Dose: 200 mg/day orally
Pediatric Dosing
should not be used in children under 6 months
Nausea/vomiting
- Oral: 0.5 to 1mg/kg/dose every 4 to 6 hours as needed.
- IM or IV: 0.5 to 1mg/kg/dose every 6 to 8 hours
Maximum recommended doses
- less than 5 years (less than 22.7 kg): 40 mg/day
- 5 and older (22.7-45.5 kg): 75 mg/day
Special Populations
- Pregnancy Rating: C
- Lactation risk: drug is excreted in breast milk; patients should discuss with physician risks/benefits if breastfeeding
Indications
- Nausea/vomiting
- intractable hiccups
- psychosis
Contraindications
- Allergy to class/drug
Adverse Reactions
- Extrapyramidal reactions (e.g., Parkinson-like symptoms, dystonia, akathisia, tardive dyskinesia), drowsiness, dizziness, skin reactions or rash, dry mouth, orthostatic hypotension, amenorrhea, galactorrhea, weight gain.
References
- Chlorpromazine. Retrieved from http://www.drugs.com/cdi/chlorpromazine.html
- US National Library of Medicine. Chlorpromazine: MedlinePlus Drug Information. Retrieved from https://www.nlm.nih.gov/medlineplus/druginfo/meds/a682040.html.
- P Young. The ICU Drug Manual. Chlorpromazine. Retrieved from http://lifeinthefastlane.com/book/critical-care-drugs/chlorpromazine/