Chlorpromazine

Revision as of 15:09, 14 January 2016 by NicoleZadzilka (talk | contribs) (Created page with "==Uses== *Nausea/vomiting *intractable hiccups *psychosis ==Administration== *Dosage Forms: 25 mg/mL IV solution; 25 mg/5 mL oral solution; 10, 25, and 100 mg tablets *Routes...")
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

Uses

  • Nausea/vomiting
  • intractable hiccups
  • psychosis

Administration

  • Dosage Forms: 25 mg/mL IV solution; 25 mg/5 mL oral solution; 10, 25, and 100 mg tablets
  • Routes of Administration: PO, IM, IV
  • Common Trade Names: Thorazine

Adult Dosing

  • Nausea/vomiting: Oral: 10 to 25 mg every 4 to 6 hours as needed. May increase, if necessary. IM: 25 mg one time. If no hypotension occurs, give 25 to 50 mg every 3 to 4 hours as needed, then switch to oral dosage. IV: 2 mg at 2 minute intervals. Do not exceed 25 mg. Dilute to 1 mg/mL.
  • Hiccups: Oral: 25 to 50 mg 3 to 4 times a day. IM: If symptoms persist for 2 to 3 days, give 25 to 50 mg IM. IV infusion: Should symptoms persist, use slow IV infusion: 25 to 50 mg in 500 to 1000 mL of saline.
  • Psychosis: IM: Initial Dose 25 to 50 mg. The dose may be repeated in one hour. Subsequent doses may be increased and given every 2 to 4 hours as needed. Oral: Initial Dose: 10 to 25 mg orally 3 times a day. Total daily doses should be increased in 20 to 50 mg increments every 3 or 4 days until symptoms are controlled.

Usual Maintenance Dose: 200 mg/day orally

Pediatric Dosing

  • should not be used in children under 6 months
  • Nausea/vomting: Nausea and vomiting: Oral: 0.5 to 1 mg/kg/dose every 4 to 6 hours as needed. IM or IV: 0.5 to 1 mg/kg/dose every 6 to 8 hours

Maximum recommended doses: less than 5 years (less than 22.7 kg): 40 mg/day 5 and older (22.7-45.5 kg): 75 mg/day

Special Populations

Contraindications

  • Allergy to class/drug

Adverse Reactions

  • Extrapyramidal reactions (e.g., Parkinson-like symptoms, dystonia, akathisia, tardive dyskinesia), drowsiness, dizziness, skin reactions or rash, dry mouth, orthostatic hypotension, amenorrhea, galactorrhea, weight gain.

References