Chorea

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Background

  • Movement disorder

Causes of Chorea

Behavioral

  • Tourette
  • Behavioral or emotional disorders

Autoimmune or inflammatory

Cerebrovascular

Infectious

  • AIDS-related
  • Cruetzfeld-Jakob disease or other prion disease
  • Diphtheria
  • Legionnaire disease
  • Lyme disease
  • Malaria
  • Neurocysticercosis
  • Neurosyphilis
  • Progressive multifocal leukoencephalopathy
  • Toxoplasmosis
  • Tuberculosis

Metabolic/Endocrine

Drugs & Toxins

Paraneoplastic

  • Neoplasm with basal ganglia involvement
  • Small-cell lung cancer

Clinical Features

A case of Chorea-acanthocytosis: (A–C) Sequential snapshots from video demonstrating involuntary movements with closure of both eyes and lower-lip biting.Note: Lower-lip ulcer can be clearly seen in (A).
  • Involuntary worm-like movements

Differential Diagnosis

Movement Disorders and Other Abnormal Contractions

Evaluation

Management

Treat the underlying disorder

Disposition

  • Consult Neurology if cause is unclear

See Also

References

  1. Miranda M, et al. Oral contraceptive induced chorea: another condition associated with anti-basal ganaglia antibodies. J Neurol Neurosurg Psychiatry 2004; 75(2): 327-328
  2. Bordelon YM, et al. Movement disorders in pregnancy. Semin Neurol 2007; 27(5):467-475
  3. Chang MH, et al. Non-ketotic hyperglycaemic chorea: a SPECT study. J Neurol neurosurg Psychiatry 1996; 60(4): 428-430