Difference between revisions of "Chronic myeloid leukemia"

(Created page with "==Background== *aka chronic myelogenous leukemia, chronic myelocytic leukemia *More common in older patients ==Clinical Features== *Usually progresses through 3 stages: *Chro...")
 
m (Rossdonaldson1 moved page Chronic Myeloid Leukemia to Chronic myeloid leukemia over redirect)
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Revision as of 05:55, 24 September 2016

Background

  • aka chronic myelogenous leukemia, chronic myelocytic leukemia
  • More common in older patients

Clinical Features

  • Usually progresses through 3 stages:
  • Chronic phase
    • Asymptomatic or indolent, nonspecific symptoms
    • Malaise, fatigue, weight loss, low grade fever
    • Lymphadenopathy, splenomegaly
  • Accelerated phase
    • Worsening of above symptoms due to progressive leukocytosis
    • Signs/symptoms of thrombocytopenia (e.g. petechiae, bleeding) or thrombocytosis
  • Blast crisis

Differential Diagnosis

Evaluation

  • CBC-
    • Leukocytosis: usually only moderately elevated in chronic phase (20,000-60,000)
    • Mild-moderate anemia
    • Variable platelet counts
  • Peripheral smear
  • DIC labs: coags, d-dimer, fibrinogen
  • Tumor lysis syndrome labs: BMP, uric acid, phosphate
  • Infectious workup
  • Evaluate for complications

Management

Disposition

See Also

External Links

References