Clotrimazole
Administration
- Type: Antifungal, azole
- Dosage Forms
- Topical:1% cream
- Vaginal: 100mg supp, 200mg supp; 1% cream, 2% cream
- Oropharyngeal: 10mg troche
- Routes of Administration: topical, oropharyngeal, vaginal
- Common Trade Names
- Topical: Anti-Fungal Liquid, Desenex AF Prescription Strength, FungiCURE Pump Spray, Lotrimin AF Cream, Lotrimin AF For Her, Lotrimin AF Jock Itch, Lotrimin AF Solution, Lotrimin Jock Itch Powder, MPM Anti-Fungal, Prescription Strength Cruex
- Vulvovaginal: Clotrimazole-3, Clotrimazole-7, Femcare, Gyne-Lotrimin, Gyne-Lotrimin 3 Day, Gyne-Lotrimin Combo Pack
- Oropharyngeal: Mycelex Troche
Adult Dosing
- Topical
- Candidiasis, cutaneous
- Apply bid
- Tinea
- Apply bid
- 2-4 weeks for best results with corporis, cruris, pedis, versicolor
- Candidiasis, cutaneous
- Vulvovaginal
- candidiasis, vulvovaginal
- 200mg PV qhs x3 days
- Alt: 100mg PV qhs x7 days
- Alt: 1 applicatorful 2% PV qhs x3 days
- Alt: 1 applicatorful 1% PV qhs x7-14 days
- candidiasis, vulvovaginal
- Oropharyngeal
- candidiasis treatment, oropharyngeal
- 10mg PO 5x/day x14 days
- slowly dissolve in mouth; do not chew or swallow whole
- 10mg PO 5x/day x14 days
- candidiasis prophylaxis, oropharyngeal
- 10mg PO tid
- continue for duration of chemo or high-dose steroid; slowly dissolve in mouth; do not chew or swallow whole
- 10mg PO tid
- candidiasis treatment, oropharyngeal
Pediatric Dosing
Same as adult
Special Populations
- Pregnancy Rating: B (topical, vulvovaginal), C (oropharyngeal)
- Lactation risk: Probably safe (topical, vulvovaginal), Safety unknown (oropharyngeal)
Renal Dosing
- Adult:
- Pediatric:
Hepatic Dosing
- Adult: Precaution with troches. Monitor LFTs.
- Pediatric:
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
may occur but none reported
Common
- Topical
- irritation
- burning/stinging
- pruritus
- erythema
- localized edema
- urticaria
- peeling
- blistering
- Vulvovaginal
- vulvovaginal burning
- vulvovaginal pruritus
- vulvovaginal soreness
- vulvovaginal swelling
- pelvic pain
- pelvic cramps
- abdominal pain
- Oropharyngeal
- vomiting
- nausea
- abdominal cramps
- abnormal LFTs
Pharmacology
- Half-life: Unknown
- Metabolism: liver; CYP450: unknown; Info: minimal systemic absorption
- Excretion: bile/feces primarily, urine
Mechanism of Action
- Exact mechanism of action unknown
- Azole antifungal
- Inhibits 14-alpha demethylase, reducing fungal cell membrane ergosterol synthesis and increasing cellular permeability
Comments
See Also
References
- Epocrates: clotrimazole-oropharyngeal
- Epocrates:clotrimazole-topical
- Epocrates: clotrimazole-vaginal