Cloxacillin: Difference between revisions
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==General== | ==General== | ||
*Type: Beta lactamase resistant penicillins | *Type: Beta lactamase resistant penicillins | ||
*Dosage Forms: | *Dosage Forms: 125mg/5 ml oral powder, 250mg, 500mg | ||
*Common Trade Names: Cloxapen, Dry Clox, Tegopen | *Common Trade Names: Cloxapen, Dry Clox, Tegopen | ||
==Adult Dosing== | ==Adult Dosing== | ||
===Upper Respiratory Tract Infection=== | ===Upper Respiratory Tract Infection=== | ||
* | *250mg PO q6hrs for 7-14 days | ||
===Pneumonia=== | ===Pneumonia=== | ||
* | *500mg PO q6hrs for up to 21 days | ||
===Soft tissue/skin infection=== | ===Soft tissue/skin infection=== | ||
* | *500mg PO q6hrs for 7 days or until 3 days after acute inflammation resolves | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===Upper Respiratory Tract Infection=== | ===Upper Respiratory Tract Infection=== | ||
*>=1 yr to 18 yrs: 50- | *>=1 yr to 18 yrs: 50-100mg/kg/day orally divided every 6 hrs, Max dose 4g/day | ||
===Soft tissue and skin infection === | ===Soft tissue and skin infection=== | ||
*>=1 yr to 18 yrs: 50- | *>=1 yr to 18 yrs: 50-100mg/kg/day orally divided every 6 hrs, Max dose 4g/day | ||
==Special Populations== | ==Special Populations== | ||
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===Common=== | ===Common=== | ||
*nausea, vomiting | |||
*diarrhea, abdominal pain | |||
*thrush/yeast infection | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 30 min - 1 hr | ||
*Metabolism: | *Metabolism: partially metabolized | ||
*Excretion: | *Excretion: renal and biliary | ||
*Mechanism of Action: | *Mechanism of Action: bactericidal; adheres to penicillin-binding proteins inhibiting bacterial cell wall synthesis | ||
==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>== | ==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>== | ||
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==See Also== | ==See Also== | ||
== | ==References== | ||
<references/> | <references/> | ||
[[Category: | [[Category:Pharmacology]] | ||
[[Category:ID]] |
Latest revision as of 17:46, 20 September 2019
General
- Type: Beta lactamase resistant penicillins
- Dosage Forms: 125mg/5 ml oral powder, 250mg, 500mg
- Common Trade Names: Cloxapen, Dry Clox, Tegopen
Adult Dosing
Upper Respiratory Tract Infection
- 250mg PO q6hrs for 7-14 days
Pneumonia
- 500mg PO q6hrs for up to 21 days
Soft tissue/skin infection
- 500mg PO q6hrs for 7 days or until 3 days after acute inflammation resolves
Pediatric Dosing
Upper Respiratory Tract Infection
- >=1 yr to 18 yrs: 50-100mg/kg/day orally divided every 6 hrs, Max dose 4g/day
Soft tissue and skin infection
- >=1 yr to 18 yrs: 50-100mg/kg/day orally divided every 6 hrs, Max dose 4g/day
Special Populations
- Pregnancy Rating: Pregnancy Category B
- Lactation: acceptable to use during breastfeeding
- Renal Dosing: no adjustments needed
- Hepatic Dosing: no adjustments needed
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- allergic reaction
- seizures
- pseudomembranous colitis
- neutropenia
- leukopenia
- thrombocytopenia
- cholestatic hepatitis
- hypersensitivity reaction
Common
- nausea, vomiting
- diarrhea, abdominal pain
- thrush/yeast infection
Pharmacology
- Half-life: 30 min - 1 hr
- Metabolism: partially metabolized
- Excretion: renal and biliary
- Mechanism of Action: bactericidal; adheres to penicillin-binding proteins inhibiting bacterial cell wall synthesis
Antibiotic Sensitivities[1]
Key
- S susceptible/sensitive (usually)
- I intermediate (variably susceptible/resistant)
- R resistant (or not effective clinically)
- S+ synergistic with cell wall antibiotics
- U sensitive for UTI only (non systemic infection)
- X1 no data
- X2 active in vitro, but not used clinically
- X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
- X4 active in vitro, but not clinically effective for strep pneumonia
See Also
References
- ↑ Sanford Guide to Antimicrobial Therapy 2014