Cobalt toxicity

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Background

  • Cobalt is essential for life as a catalytic center for vitamin B12. Toxicity is rare.
  • Cobalt toxicity has been reported through the following exposures:[1]
    • Orthopedic hip prostheses containing cobalt
    • Work-related cobalt exposure
    • Excessive drinking of beer containing cobalt sulfate

Clinical Features[2]

  • Neurologic Dysfunction
    • Hearing impairment
    • Cognitive impairment
    • Parasthesias
  • Cardiovascular Dysfunction
  • Thyroid Dysfunction

Differential Diagnosis

Heavy metal toxicity

Evaluation

Management

There is no consensus regarding treatment of patients with systemic symptoms of cobalt toxicity[3]

Disposition

See Also

External Links

References

  1. Simonsen, L., 2012. Cobalt metabolism and toxicology—A brief update.
  2. Devlin, J., 2021. Clinical Features, Testing, and Management of Patients with Suspected Prosthetic Hip-Associated Cobalt Toxicity: a Systematic Review of Cases.
  3. Dwyer, J., 2021. Final Diagnosis-Elevated Blood Cobalt Levels in Patients with Metal-on-Metal Prosthesis. [online] Available at: <https://path.upmc.edu/cases/case806/dx.html> [Accessed 28 June 2021].
  4. Mohan, N., 2016. Identification and Management of Cobalt Toxicity: A Case Report of Rapidly Progressing Toxicity after Hip Arthroplasty Revision. [online] Jdc.jefferson.edu. Available at: <https://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1359&context=tmf> [Accessed 28 June 2021].